Target Details
| UniProt AC | Q08209 |
|---|---|
| Gene Symbol | PPP3CA |
| Protein Name | Protein phosphatase 3 catalytic subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00149 (Metallophos) |
Summary
- Multi-target molecules 4
- Clinical molecules 0
- Avg pChEMBL 7.08
KEGG Pathways (33)
- Alzheimer disease
- Amphetamine addiction
- Amyotrophic lateral sclerosis
- Axon guidance
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Calcium signaling pathway
- Cellular senescence
- Dopaminergic synapse
- Glucagon signaling pathway
- Glutamatergic synapse
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Long-term potentiation
- MAPK signaling pathway
- Natural killer cell mediated cytotoxicity
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Renin secretion
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tuberculosis
- VEGF signaling pathway
- Wnt signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (3)
Active Molecules (4)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QJJXYPPXXYFBGM
|
7.8 | IC50 | 11 | — | |
PMATZTZNYRCHOR
|
7.6 | IC50 | 20 | — | |
PFWOYZZGFBYUBT
|
6.5 | Kd | 2 | — | |
RNAVJUXBBIBAEL
|
6.5 | Kd | 2 | — |