Target Details
| UniProt AC | Q06124 |
|---|---|
| Gene Symbol | PTPN11 |
| Protein Name | Tyrosine-protein phosphatase non-receptor type 11 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00017 (SH2) PF00102 (Y_phosphatase) |
Summary
- Multi-target molecules 214
- Clinical molecules 1
- Avg pChEMBL 7.2
KEGG Pathways (21)
- Adipocytokine signaling pathway
- Axon guidance
- C-type lectin receptor signaling pathway
- Chemical carcinogenesis - reactive oxygen species
- Chronic myeloid leukemia
- Efferocytosis
- Epithelial cell signaling in Helicobacter pylori infection
- Herpes simplex virus 1 infection
- IgSF CAM signaling
- Insulin resistance
- JAK-STAT signaling pathway
- Leukocyte transendothelial migration
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Ras signaling pathway
- Renal cell carcinoma
- T cell receptor signaling pathway
Associated Diseases (6)
Active Molecules (214)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XDVMDMDHVZOAMP
|
6.5 | IC50 | 2 | — | |
QIRQGNZQWCVFAG
|
6.5 | IC50 | 2 | — | |
JQWPQEJDTUKOCS
|
6.5 | IC50 | 2 | — | |
LNKXXCNDICLLOS
|
6.5 | IC50 | 2 | — | |
NHGRNRILMHNSIR
|
6.5 | IC50 | 2 | — | |
KCRBJSWWABFQLC
|
6.5 | IC50 | 2 | — | |
OPHYBUHBYGTOAL
|
6.5 | IC50 | 3 | — | |
QEAYLNJEDDOYNQ
|
6.5 | IC50 | 2 | — | |
SEYQXKIRSCBUBZ
|
6.5 | IC50 | 3 | — | |
STWOQVDTSIRUNC
|
6.4 | IC50 | 2 | — | |
BDJJZYXDJQVPIV
|
6.4 | IC50 | 2 | — | |
KJRKWHJEHFSIPH
|
6.4 | IC50 | 2 | — | |
ZIIMUYFKCXJFPR
|
6.4 | IC50 | 2 | — | |
GROJNADPOMHDCI
|
6.4 | IC50 | 2 | — | |
INLVNBHMUINFBA
|
6.4 | IC50 | 2 | — | |
DCZHDAUEYSJCLK
|
6.4 | IC50 | 2 | — | |
YJOYTQQCKRNIPB
|
6.4 | IC50 | 2 | — | |
ZLSAGPLZHAPKDO
|
6.4 | IC50 | 2 | — | |
KRYBHQBUWQPDQQ
|
6.4 | IC50 | 2 | — | |
HOHZNTPITAYQEZ
|
6.4 | IC50 | 2 | — | |
VZRHEZSOEBDPOH
|
6.4 | IC50 | 2 | — | |
KGOAMMKJVQZGLF
|
6.3 | IC50 | 2 | — | |
BFJXGNDCJKJBPA
|
6.3 | IC50 | 2 | — | |
AVMJNCJSYBFURN
|
6.3 | IC50 | 4 | Yes | |
VDWPBBYWLISYQY
|
6.3 | IC50 | 2 | — | |
VXGZSGLWNWPMRM
|
6.3 | IC50 | 2 | — | |
JNCPSODLWJEFQC
|
6.3 | IC50 | 5 | — | |
HILFUTGZGNSLCF
|
6.3 | IC50 | 2 | — | |
IUKCEVLFGQASRB
|
6.3 | IC50 | 2 | — | |
HXKDFUSJAFLWKF
|
6.3 | IC50 | 2 | — | |
LVBIHNDCEXHSGZ
|
6.3 | IC50 | 2 | — | |
MGKIMAOKUSXGGL
|
6.3 | IC50 | 2 | — | |
ZAKVHDWXAFAMTH
|
6.2 | IC50 | 8 | — | |
ABECVSURQGZTBR
|
6.2 | IC50 | 2 | — | |
FKZHXROWVQMDAU
|
6.2 | IC50 | 2 | — | |
WVNQJOXFTBTXOE
|
6.2 | IC50 | 6 | — | |
FHXHSGHVLJCOPB
|
6.2 | IC50 | 2 | — | |
YFIASUMJKJCVBV
|
6.2 | IC50 | 2 | — | |
ZOCBTZIMNNTWDS
|
6.2 | IC50 | 3 | — | |
GNFIPHCOJWSBRQ
|
6.2 | IC50 | 2 | — | |
FKZOMXXYVRQPKU
|
6.2 | IC50 | 2 | — | |
FQMKKDYJAKJVRO
|
6.2 | Ki | 2 | — | |
UTBADYWVJGFMEB
|
6.2 | IC50 | 2 | — | |
HNDWHMKTONQBSA
|
6.2 | IC50 | 3 | — | |
MURWJADXFXGPIX
|
6.2 | IC50 | 3 | — | |
CCGJOMGWGAAKFE
|
6.2 | IC50 | 2 | — | |
IAXVMRDEFVJSDB
|
6.2 | IC50 | 2 | — | |
PBERWSCWYDTVLM
|
6.1 | IC50 | 2 | — | |
HKNBZZHPBSDXCE
|
6.1 | IC50 | 2 | — | |
BKPNRKXXSDKCRM
|
6.1 | IC50 | 2 | — |