Target Details
| UniProt AC | Q05586 |
|---|---|
| Gene Symbol | GRIN1 |
| Protein Name | Glutamate receptor ionotropic, NMDA 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01094 (ANF_receptor) PF00060 (Lig_chan) PF10613 (Lig_chan-Glu_bd) |
Summary
- Multi-target molecules 1,847
- Clinical molecules 2
- Avg pChEMBL 7.16
KEGG Pathways (19)
- Alcoholism
- Alzheimer disease
- Amphetamine addiction
- Amyotrophic lateral sclerosis
- Calcium signaling pathway
- Circadian entrainment
- Cocaine addiction
- Glutamatergic synapse
- Huntington disease
- Long-term potentiation
- Neuroactive ligand signaling
- Neuroactive ligand-receptor interaction
- Nicotine addiction
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Rap1 signaling pathway
- Ras signaling pathway
- Spinocerebellar ataxia
- cAMP signaling pathway
Associated Diseases (4)
Active Molecules (1,847)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IBBJZQQQBBTMSD
|
7.7 | IC50 | 2 | — | |
INOYCBNLWYEPSB
|
7.7 | Ki | 2 | — | |
JHRSKNHYYJXNAP
|
7.7 | IC50 | 3 | — | |
JMOAYVOBMBWNMX
|
7.7 | IC50 | 3 | — | |
KOQOZRWNLDVJDP
|
7.7 | IC50 | 3 | — | |
LPGSMIDPLVVEOA
|
7.7 | IC50 | 2 | — | |
LTQTZHVGIAPGCH
|
7.7 | IC50 | 3 | — | |
PZWIDHYFDZPUMO
|
7.7 | IC50 | 2 | — | |
RKFDMAFHXUKWFT
|
7.7 | IC50 | 2 | — | |
SJEHNWGEZJSGGR
|
7.7 | IC50 | 3 | — | |
TXJXBHIKBDZABF
|
7.7 | IC50 | 2 | — | |
TXRVVAFJUFYXIG
|
7.7 | IC50 | 2 | — | |
XXVQFSMGGVMWLV
|
7.7 | IC50 | 2 | — | |
ZQEZTCLUXNHMCA
|
7.7 | IC50 | 2 | — | |
OUSQSVNCEDHXMJ
|
7.7 | Ki | 10 | — | |
QBGJXSOFTRVLIT
|
7.7 | Ki | 7 | — | |
DREAGQJUVYPIJQ
|
7.6 | IC50 | 3 | — | |
DVEIBKQAXUNVHU
|
7.6 | IC50 | 3 | — | |
GCHXTEIDUFZVEP
|
7.6 | IC50 | 2 | — | |
HTNDZVBGOHIKCF
|
7.6 | IC50 | 2 | — | |
IITSEHBVCHOHKB
|
7.6 | IC50 | 3 | — | |
JEJIBWJJCWXPTN
|
7.6 | IC50 | 2 | — | |
JTJMJGYZQZDUJJ
|
7.6 | Ki | 9 | — | |
KKCRGJQSXQBZEZ
|
7.6 | IC50 | 2 | — | |
KQDCJFVXGJPAGK
|
7.6 | IC50 | 2 | — | |
OKJPXVUYSUJGNN
|
7.6 | IC50 | 7 | — | |
PVOQMOZBTUTFRC
|
7.6 | IC50 | 2 | — | |
UJAPXGRIXJRPCK
|
7.6 | IC50 | 2 | — | |
WNABTJJKHWFLAA
|
7.6 | IC50 | 2 | — | |
XSLQGRLIVLDGLY
|
7.6 | Ki | 2 | — | |
CPOZSLOOQHUUPD
|
7.6 | IC50 | 2 | — | |
AFLMEDYILBVTLD
|
7.6 | IC50 | 7 | — | |
CAQXELHWIMPARY
|
7.6 | IC50 | 2 | — | |
KBMHIIGNNRUHMZ
|
7.6 | IC50 | 2 | — | |
SINNKSZURBXUGH
|
7.6 | IC50 | 2 | — | |
SOCALSARJOFIGL
|
7.6 | IC50 | 3 | — | |
XGCIWNYJAXZXRA
|
7.6 | IC50 | 3 | — | |
ATMXBHJDBUAPJV
|
7.6 | IC50 | 2 | — | |
CCDQRLFAEQAGPD
|
7.6 | IC50 | 2 | — | |
GWYQRPMZDOMUSF
|
7.6 | IC50 | 2 | — | |
HEXBAJSBFNYKJO
|
7.6 | IC50 | 2 | — | |
HEXBAJSBFNYKJO
|
7.6 | IC50 | 2 | — | |
HXWFXQBXTRMISY
|
7.6 | IC50 | 3 | — | |
ISGNQURUMOYRMQ
|
7.6 | IC50 | 2 | — | |
KJMJZRGVFRRAFE
|
7.6 | IC50 | 2 | — | |
KVKDWYWBOKOSHV
|
7.6 | IC50 | 3 | — | |
PWLGLCFRIPHQAO
|
7.6 | IC50 | 2 | — | |
SAIWFWYKRTXNCD
|
7.6 | IC50 | 2 | — | |
WFBWOHGLKPPKMS
|
7.6 | IC50 | 3 | — | |
YOEBHXAPPNTAQD
|
7.6 | IC50 | 2 | — |