Target Details
| UniProt AC | Q05513 |
|---|---|
| Gene Symbol | PRKCZ |
| Protein Name | Protein kinase C zeta type |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF00564 (PB1) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 166
- Clinical molecules 93
- Avg pChEMBL 7.14
KEGG Pathways (16)
- AGE-RAGE signaling pathway in diabetic complications
- Axon guidance
- Chemokine signaling pathway
- Diabetic cardiomyopathy
- Endocytosis
- Fluid shear stress and atherosclerosis
- Hippo signaling pathway
- Human papillomavirus infection
- Insulin resistance
- Insulin signaling pathway
- Platelet activation
- Rap1 signaling pathway
- Relaxin signaling pathway
- Sphingolipid signaling pathway
- Tight junction
- Type II diabetes mellitus
Active Molecules (166)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WTXAWDOYPWWUJL
|
10.1 | IC50 | 11 | — | |
SSXCVTWCXHGTLK
|
9.9 | IC50 | 11 | — | |
KTGVSZYYHHRRGW
|
9.8 | IC50 | 11 | — | |
VIESIZQAHOPEBR
|
9.8 | IC50 | 11 | — | |
NVYBXIDWOJVGQI
|
9.8 | IC50 | 11 | — | |
APVOCXHEVZBCGS
|
9.7 | IC50 | 11 | — | |
XKVKEBRJQBYODL
|
9.7 | IC50 | 2 | — | |
DHTLXMRCLSUJPP
|
9.7 | IC50 | 11 | — | |
VVRRZOFLLJAMIK
|
9.4 | IC50 | 11 | — | |
KWKHZFAYBPSEGP
|
9.3 | IC50 | 2 | — | |
MESYXTDMWTWQNS
|
9.2 | IC50 | 2 | — | |
NVSJOASGKCGXBZ
|
8.8 | IC50 | 16 | Yes | |
QYBVZIIWBRIXMX
|
8.7 | IC50 | 12 | Yes | |
JZLFYMHIISZQCZ
|
8.7 | IC50 | 12 | Yes | |
KKMLIJHOUUKCSW
|
8.7 | IC50 | 2 | — | |
JRZRHWNUPAZFMZ
|
8.4 | IC50 | 2 | — | |
XYUFCXJZFZPEJD
|
8.3 | Ki | 23 | Yes | |
IAHVSHNBRRKKBX
|
8.2 | IC50 | 2 | — | |
BQJRUJTZSGYBEZ
|
8.2 | Kd | 13 | Yes | |
SAYMBMAHSBYKKR
|
8.2 | IC50 | 12 | Yes | |
XKVKEBRJQBYODL
|
8.2 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
8.1 | IC50 | 408 | — | |
POTTVLREWUNNRO
|
8.1 | IC50 | 17 | Yes | |
CDXNZQYZADSNCP
|
8.0 | IC50 | 12 | Yes | |
DSXXEELGXBCYNQ
|
8.0 | IC50 | 28 | Yes | |
FFKRSNGYONHGEV
|
8.0 | IC50 | 12 | Yes | |
OPQUGNXQOSDRMT
|
8.0 | IC50 | 12 | Yes | |
PGWBJRRPIUVOAD
|
8.0 | IC50 | 12 | Yes | |
RFUHKEPWGZUNBG
|
8.0 | IC50 | 4 | — | |
VVENTSJOKWJQFG
|
7.9 | IC50 | 2 | — | |
PBCZSGKMGDDXIJ
|
7.9 | IC50 | 14 | Yes | |
WLYQNZYLNRAMFN
|
7.9 | IC50 | 2 | — | |
GPGZMTPPOHCJRE
|
7.8 | IC50 | 16 | Yes | |
SMZYTCQRZVNFFJ
|
7.8 | IC50 | 16 | Yes | |
CXSQMXRQOZZFLD
|
7.8 | IC50 | 18 | — | |
PBCZSGKMGDDXIJ
|
7.8 | IC50 | 68 | Yes | |
FXGHOAZJQNLNFD
|
7.8 | IC50 | 13 | Yes | |
AZIMEXGKUWHPQV
|
7.7 | IC50 | 12 | Yes | |
FSBMWCWKNXQVMP
|
7.7 | IC50 | 12 | Yes | |
LRZYYIZFBXFSJB
|
7.7 | Ki | 69 | — | |
YUKJJLKBBAFYNN
|
7.7 | IC50 | 12 | Yes | |
RQXOBAMSPDGWSL
|
7.7 | IC50 | 6 | — | |
ADMFLILDQJSEIK
|
7.6 | Ki | 72 | — | |
YOVNFNXUCOWYSG
|
7.6 | Ki | 33 | Yes | |
KPCVAMMFCPIUIU
|
7.5 | IC50 | 12 | Yes | |
XXDWSQPJTJZKSJ
|
7.5 | IC50 | 12 | Yes | |
ZZSBPGIGIUFJRA
|
7.5 | IC50 | 15 | Yes | |
FELQRVDTGNDOSI
|
7.5 | IC50 | 15 | Yes | |
MYOUXQLHWTWXON
|
7.5 | IC50 | 16 | Yes | |
YDZJEODKNRAYMA
|
7.5 | IC50 | 12 | Yes |