Target Details
| UniProt AC | Q05397 |
|---|---|
| Gene Symbol | PTK2 |
| Protein Name | Focal adhesion kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF21477 (FERM_C_FAK1) PF00373 (FERM_M) PF18038 (FERM_N_2) PF03623 (Focal_AT) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 325
- Clinical molecules 26
- Avg pChEMBL 6.99
KEGG Pathways (28)
- Amoebiasis
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Efferocytosis
- Endocrine resistance
- ErbB signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Growth hormone synthesis, secretion and action
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Integrin signaling
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Small cell lung cancer
- Transcriptional misregulation in cancer
- VEGF signaling pathway
- Yersinia infection
Active Molecules (325)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AWDBBSCWWQJPMJ
|
6.0 | IC50 | 2 | — | |
CGKOJXZSERSZFD
|
6.0 | IC50 | 3 | — | |
CGPMWUPWDLVLFB
|
6.0 | IC50 | 3 | — | |
DNPZJPXOXCQXPR
|
6.0 | IC50 | 2 | — | |
DRBLSGJGTGHHCV
|
6.0 | IC50 | 3 | — | |
GZWAVMOEACERMF
|
6.0 | IC50 | 3 | — | |
HBWXPYGLVGQEFC
|
6.0 | IC50 | 3 | — | |
IICBGMWCBQZMKR
|
6.0 | IC50 | 3 | — | |
IOBVCHJTLVPPBR
|
6.0 | Ki | 39 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
NMHMCXTYPRADBA
|
6.0 | Ki | 20 | — | |
OBYQEAJRBHZJFM
|
6.0 | IC50 | 3 | — | |
QPTZMGCTRHKKJD
|
6.0 | Ki | 3 | — | |
QYLHIQHJHCIUAA
|
6.0 | IC50 | 3 | — | |
RJHRDUJEFJMNON
|
6.0 | IC50 | 2 | — | |
RXUNRNOYWJETLW
|
6.0 | IC50 | 3 | — | |
SEVCBWKJSOLMNQ
|
6.0 | Ki | 38 | — | |
SFZNJQIXJINAKW
|
6.0 | IC50 | 2 | — | |
UCSSSNQXDXUOCP
|
6.0 | IC50 | 2 | — | |
UXYXTSNQTKUIAG
|
6.0 | IC50 | 2 | — | |
VFRBZPIMVLVQNZ
|
6.0 | IC50 | 3 | — | |
XKAQVMPWGGIKDK
|
6.0 | IC50 | 3 | — | |
YCLQARKYPSNTHA
|
6.0 | IC50 | 3 | — | |
YDWMUCKJUNLURC
|
6.0 | Ki | 24 | — | |
ZCCJKVBTHCOISJ
|
6.0 | Ki | 46 | — |