Target Details
| UniProt AC | Q05397 |
|---|---|
| Gene Symbol | PTK2 |
| Protein Name | Focal adhesion kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF21477 (FERM_C_FAK1) PF00373 (FERM_M) PF18038 (FERM_N_2) PF03623 (Focal_AT) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 325
- Clinical molecules 26
- Avg pChEMBL 6.99
KEGG Pathways (28)
- Amoebiasis
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Efferocytosis
- Endocrine resistance
- ErbB signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Growth hormone synthesis, secretion and action
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Integrin signaling
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Small cell lung cancer
- Transcriptional misregulation in cancer
- VEGF signaling pathway
- Yersinia infection
Active Molecules (325)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
UBPYILGKFZZVDX
|
6.2 | Kd | 130 | Yes | |
VAUHRGCAUAQDDS
|
6.2 | IC50 | 3 | — | |
BIRREBZZUBOXQS
|
6.2 | IC50 | 3 | — | |
DQLZJRWBFFYECR
|
6.2 | IC50 | 3 | — | |
KQLHECVWPJTIGF
|
6.2 | IC50 | 2 | — | |
SXNJFOWDRLKDSF
|
6.2 | Kd | 8 | — | |
BBZHHJCMVZXOQN
|
6.2 | IC50 | 2 | — | |
DSSRVQAIWBZWON
|
6.2 | Ki | 9 | — | |
LCGSWTFWYNYUKS
|
6.2 | Ki | 26 | — | |
VSVWQTDDGQSGHP
|
6.2 | Ki | 51 | — | |
XLFYOIVELARSKP
|
6.2 | Ki | 33 | — | |
SRLAWDYDLHMAMZ
|
6.2 | IC50 | 2 | — | |
DPDRIPIWHJZODU
|
6.2 | IC50 | 2 | — | |
JDMBOHIMNYUIJK
|
6.2 | IC50 | 2 | — | |
QHFHNVUOAPKMLZ
|
6.2 | IC50 | 3 | — | |
BHORRHKXIFYQMT
|
6.2 | IC50 | 3 | — | |
HNQDVIYDZGTLTL
|
6.2 | IC50 | 3 | — | |
PPWUHEVYHPGQSX
|
6.2 | IC50 | 3 | — | |
BJRRXLJCIAUKMM
|
6.1 | IC50 | 2 | — | |
VBMFQCUNBFXLPF
|
6.1 | IC50 | 3 | — | |
WDBHENZTEUAYHU
|
6.1 | IC50 | 3 | — | |
UBKZBHKUADPBKN
|
6.1 | IC50 | 3 | — | |
ACZYOIGOUSQCEZ
|
6.1 | IC50 | 2 | — | |
AUDNGNGLLRZLDR
|
6.1 | Ki | 33 | — | |
CQBBMNXXVMOFCA
|
6.1 | Ki | 39 | — | |
CZGMEOAMQWAJOY
|
6.1 | IC50 | 15 | Yes | |
GNLAGGCSJGJECE
|
6.1 | Ki | 19 | Yes | |
LVECPYVAIBNSRV
|
6.1 | Ki | 33 | — | |
SFPWNTQWFFNJIH
|
6.1 | Ki | 48 | — | |
TZOUTHMCVDKWLH
|
6.1 | IC50 | 2 | — | |
UIRCQOKSJDLYBB
|
6.1 | Ki | 50 | — | |
ULHGAQSVFPOUDY
|
6.1 | Ki | 43 | — | |
VNDWQCSOSCCWIP
|
6.1 | Ki | 39 | Yes | |
IAHRSPNDVKURFK
|
6.1 | IC50 | 2 | — | |
XDNCIFYMMJWWTA
|
6.1 | IC50 | 3 | — | |
XNUMRPLPPUXQNR
|
6.1 | IC50 | 2 | — | |
HZHMSBKFDZWRLC
|
6.1 | IC50 | 2 | — | |
YGCBKXMSJGVSNG
|
6.1 | IC50 | 3 | — | |
ZTWLETHVLGNRKG
|
6.1 | IC50 | 3 | — | |
FRHDZWLQTMKUPC
|
6.0 | IC50 | 11 | Yes | |
SEZFNTZQMWJIAI
|
6.0 | Ki | 22 | — | |
YIGQSLKUNKHIBI
|
6.0 | IC50 | 2 | — | |
YZUQFAROCPSMBL
|
6.0 | IC50 | 3 | — | |
HUFMQXVFIMXNJK
|
6.0 | IC50 | 3 | — | |
DHEIXKMEIJGYCU
|
6.0 | IC50 | 2 | — | |
DSXZRXGQDUOYMH
|
6.0 | IC50 | 2 | — | |
IAFPLLCIBBXSHE
|
6.0 | IC50 | 3 | — | |
IAYGCINLNONXHY
|
6.0 | Kd | 50 | — | |
ISXAVIPPPMJTPN
|
6.0 | IC50 | 2 | — | |
URSLEHKVHAOWPQ
|
6.0 | IC50 | 3 | — |