Target Details
| UniProt AC | Q05397 |
|---|---|
| Gene Symbol | PTK2 |
| Protein Name | Focal adhesion kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF21477 (FERM_C_FAK1) PF00373 (FERM_M) PF18038 (FERM_N_2) PF03623 (Focal_AT) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 325
- Clinical molecules 26
- Avg pChEMBL 6.99
KEGG Pathways (28)
- Amoebiasis
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Efferocytosis
- Endocrine resistance
- ErbB signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Growth hormone synthesis, secretion and action
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Integrin signaling
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Small cell lung cancer
- Transcriptional misregulation in cancer
- VEGF signaling pathway
- Yersinia infection
Active Molecules (325)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HHJSKDRCUMVWKF
|
6.8 | IC50 | 7 | — | |
LRLOMPHFTKHYKN
|
6.8 | IC50 | 10 | Yes | |
XQVVPGYIWAGRNI
|
6.8 | Kd | 34 | — | |
ZWVZORIKUNOTCS
|
6.8 | IC50 | 10 | Yes | |
BLSARKHLSUEWOW
|
6.8 | IC50 | 2 | — | |
RGNHKJWHFIPHIM
|
6.8 | Ki | 66 | — | |
XHORJSJFHVABEA
|
6.8 | Ki | 49 | — | |
NOYVLHBXTITZDL
|
6.8 | IC50 | 2 | — | |
SMOLATMZTWOLFX
|
6.8 | IC50 | 2 | — | |
VWELCPLMPPEKOL
|
6.8 | IC50 | 9 | Yes | |
CKRPEFXFIJADJE
|
6.8 | IC50 | 2 | — | |
XCJNPYULTYFKFW
|
6.8 | IC50 | 3 | — | |
CXQHYVUVSFXTMY
|
6.8 | Kd | 154 | — | |
XHVOZHLINNPOHR
|
6.8 | IC50 | 2 | — | |
SEJGTFPOEJWEGG
|
6.7 | Kd | 149 | — | |
SVZUZSDHGKVQNU
|
6.7 | IC50 | 11 | Yes | |
PDOQBOJDRPLBQU
|
6.7 | Kd | 21 | — | |
VNRMSQVOZMGKEN
|
6.7 | IC50 | 2 | — | |
VSOBEWDEAFPUPX
|
6.7 | IC50 | 2 | — | |
BIKYDWLMTPRSQL
|
6.7 | Ki | 50 | — | |
DLWMVUDMPMKGEE
|
6.7 | Ki | 24 | — | |
HJNUCQAIWCULOY
|
6.7 | IC50 | 3 | — | |
HZTYDQRUAWIZRE
|
6.7 | Kd | 40 | Yes | |
QONPPIZSNSSCSK
|
6.7 | Ki | 45 | Yes | |
XYXLUJQBBIBJFV
|
6.7 | Ki | 36 | — | |
YENZSPIOXMNEFF
|
6.7 | IC50 | 2 | — | |
ZHOXAGNPCZTRBN
|
6.7 | Kd | 20 | — | |
OBKWVNQNMBDGSL
|
6.7 | IC50 | 2 | — | |
UAIRELYYNQRVKN
|
6.7 | IC50 | 3 | — | |
XZXHXSATPCNXJR
|
6.7 | Kd | 165 | Yes | |
ZGANUHYBZBGARG
|
6.7 | IC50 | 2 | — | |
IIOMGDJIOCWANC
|
6.7 | IC50 | 3 | — | |
ACLLLJSNOCYQOJ
|
6.7 | IC50 | 8 | — | |
VERWOWGGCGHDQE
|
6.7 | Kd | 23 | — | |
NDTNQPJKGSCGGP
|
6.6 | IC50 | 3 | — | |
NHHQJBCNYHBUSI
|
6.6 | Kd | 220 | — | |
NRGYZNJPCGRCLV
|
6.6 | Ki | 52 | — | |
WVXNSAVVKYZVOE
|
6.6 | IC50 | 92 | — | |
XJSFDMGICAWQFS
|
6.6 | Ki | 60 | — | |
PFBJFDODKFDMGH
|
6.6 | IC50 | 2 | — | |
INQBVHWEOAKYED
|
6.6 | IC50 | 2 | — | |
QVEWCURGCSBRER
|
6.6 | IC50 | 4 | — | |
WKDACQVEJIVHMZ
|
6.6 | Kd | 46 | — | |
YMEIWXZVPITMOT
|
6.6 | IC50 | 3 | — | |
IZLUBQPWEKVIDI
|
6.6 | IC50 | 5 | — | |
UTILGGVSXFQUPI
|
6.6 | IC50 | 2 | — | |
BYGYBYAJUHLQRR
|
6.5 | IC50 | 2 | — | |
OEVBGOMMLVZIHM
|
6.5 | IC50 | 2 | — | |
KTEIFNKAUNYNJU
|
6.5 | Kd | 114 | — | |
OSVUGUHRKMMBSE
|
6.5 | Kd | 170 | — |