Target Details
| UniProt AC | Q05397 |
|---|---|
| Gene Symbol | PTK2 |
| Protein Name | Focal adhesion kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF21477 (FERM_C_FAK1) PF00373 (FERM_M) PF18038 (FERM_N_2) PF03623 (Focal_AT) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 325
- Clinical molecules 26
- Avg pChEMBL 6.99
KEGG Pathways (28)
- Amoebiasis
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Efferocytosis
- Endocrine resistance
- ErbB signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Growth hormone synthesis, secretion and action
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Integrin signaling
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Small cell lung cancer
- Transcriptional misregulation in cancer
- VEGF signaling pathway
- Yersinia infection
Active Molecules (325)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IGFFFJZWKLOHRI
|
7.3 | IC50 | 2 | — | |
PQISYCKBAAVHIB
|
7.3 | IC50 | 2 | — | |
ZYQANMJWXRTHQW
|
7.3 | IC50 | 3 | — | |
BLQYVHBZHAISJM
|
7.3 | IC50 | 21 | Yes | |
BLQYVHBZHAISJM
|
7.3 | IC50 | 54 | — | |
HKSZLNNOFSGOKW
|
7.3 | IC50 | 408 | — | |
JRLOPMVTMMPZMV
|
7.2 | IC50 | 6 | — | |
RYYNGWLOYLRZLK
|
7.2 | Kd | 45 | — | |
CJXWCEYBQNLEOH
|
7.2 | IC50 | 2 | — | |
QSZOUSWVOCYWSS
|
7.2 | IC50 | 3 | — | |
VCFDMLBPASGZTP
|
7.2 | Ki | 38 | — | |
HKSZLNNOFSGOKW
|
7.2 | Kd | 213 | — | |
VKBFHTIUXUCYRQ
|
7.2 | Ki | 66 | — | |
WGUPYSJTXMOQKK
|
7.2 | IC50 | 3 | — | |
WBYAJDDXRYYJOT
|
7.1 | IC50 | 2 | — | |
MGGBYMDAPCCKCT
|
7.1 | Kd | 23 | — | |
HZNPQJTZWHIEFN
|
7.1 | IC50 | 3 | — | |
ITTRLTNMFYIYPA
|
7.1 | Kd | 17 | — | |
QOMCHFVQYZKKTL
|
7.1 | IC50 | 2 | — | |
PTVPBWWDGZSEAF
|
7.1 | Ki | 63 | — | |
XOOAAYRIVATZNM
|
7.1 | Ki | 55 | — | |
DUBHPLWTLUVGNU
|
7.1 | IC50 | 5 | — | |
GFEWEPZLEYQMJH
|
7.1 | IC50 | 2 | — | |
APPXQUDJLJXULP
|
7.0 | IC50 | 47 | — | |
HEBHVXJRMDQONJ
|
7.0 | IC50 | 2 | — | |
SLFIVXXZOYCJGB
|
7.0 | IC50 | 3 | — | |
HKSZLNNOFSGOKW
|
7.0 | Ki | 118 | — | |
MVJMMLFMPWITEJ
|
7.0 | Ki | 110 | — | |
NKBVOEJXKSYSME
|
7.0 | IC50 | 3 | — | |
OTVCFDOYUHREFJ
|
7.0 | Ki | 26 | — | |
SUMBOYLUNPWNIC
|
7.0 | IC50 | 2 | — | |
XCHWBXBDZRJVDP
|
7.0 | Ki | 51 | — | |
JKNCXKNOUNKWSO
|
7.0 | IC50 | 2 | — | |
MYTKOMPBIZWDKF
|
7.0 | IC50 | 3 | — | |
QXJBBWIDIJSXNA
|
6.9 | IC50 | 2 | — | |
DKZYXHCYPUVGAF
|
6.9 | Kd | 112 | — | |
WXTUWRZQCBDOEW
|
6.9 | IC50 | 2 | — | |
DZPFKGQUWAWYKE
|
6.9 | IC50 | 2 | — | |
NRMBCYARFYTQTI
|
6.9 | IC50 | 3 | — | |
HZPACYSNLOCDLW
|
6.9 | Ki | 48 | — | |
MHWHPWMWKYXCRJ
|
6.9 | Ki | 32 | — | |
WPHKIQPVPYJNAX
|
6.9 | Ki | 81 | — | |
ZLHFILGSQDJULK
|
6.9 | Ki | 37 | Yes | |
ZWVZORIKUNOTCS
|
6.9 | Ki | 69 | — | |
GQQBUTCPDHQVTA
|
6.9 | IC50 | 2 | — | |
LAJAFFLJAJMYLK
|
6.9 | IC50 | 17 | — | |
OEDFDVPAQDUCBQ
|
6.9 | IC50 | 3 | — | |
UJBJWYNPUOLFIZ
|
6.9 | IC50 | 49 | — | |
YVQOYBIBWBAHKH
|
6.9 | IC50 | 12 | — | |
HAYYBYPASCDWEQ
|
6.8 | IC50 | 47 | — |