Target Details
| UniProt AC | Q05397 |
|---|---|
| Gene Symbol | PTK2 |
| Protein Name | Focal adhesion kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF21477 (FERM_C_FAK1) PF00373 (FERM_M) PF18038 (FERM_N_2) PF03623 (Focal_AT) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 325
- Clinical molecules 26
- Avg pChEMBL 6.99
KEGG Pathways (28)
- Amoebiasis
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Efferocytosis
- Endocrine resistance
- ErbB signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Growth hormone synthesis, secretion and action
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Integrin signaling
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Small cell lung cancer
- Transcriptional misregulation in cancer
- VEGF signaling pathway
- Yersinia infection
Active Molecules (325)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IZXVMYGSHYBFKM
|
8.0 | IC50 | 2 | — | |
LQVXSNNAFNGRAH
|
8.0 | Kd | 33 | Yes | |
HIOYYLSBJMMPNZ
|
8.0 | IC50 | 2 | — | |
BCSHRERPHLTPEE
|
7.9 | IC50 | 3 | — | |
LJKJYKWDLJUZHA
|
7.9 | Ki | 24 | — | |
UOVCGJXDGOGOCZ
|
7.9 | Ki | 59 | — | |
QIFRBZLXSGROBT
|
7.9 | IC50 | 3 | — | |
RGVZAYIZFFSVLT
|
7.9 | IC50 | 2 | — | |
YSCOHZQEVPHJEF
|
7.9 | IC50 | 3 | — | |
DDQHOFUNXAOJKD
|
7.8 | IC50 | 3 | — | |
DIXMBHMNEHPFCX
|
7.8 | IC50 | 12 | — | |
OPWPQZXQSROBLU
|
7.8 | IC50 | 2 | — | |
FOLRUTAUDNCQAE
|
7.8 | IC50 | 2 | — | |
IIXWYSCJSQVBQM
|
7.8 | IC50 | 18 | — | |
NRQSCGVAXSQZCR
|
7.8 | IC50 | 4 | — | |
VXYZCOCRVAQWBG
|
7.8 | IC50 | 15 | — | |
AXEVKNAHSSENFT
|
7.8 | IC50 | 5 | — | |
FZBVNCFBCNXULH
|
7.8 | IC50 | 18 | — | |
BPBXDXBTPQWBBQ
|
7.8 | IC50 | 3 | — | |
DZJALNXETIVWPB
|
7.7 | IC50 | 2 | — | |
GDRLJBDXWDATLA
|
7.7 | IC50 | 13 | — | |
DAJMEJBPGNBYEH
|
7.7 | IC50 | 2 | — | |
MWKSRKSEWLRPBL
|
7.7 | Kd | 1075 | — | |
VTFLNPMNLYUXBL
|
7.7 | IC50 | 2 | — | |
WLTMYDRAYRGWMO
|
7.7 | IC50 | 5 | — | |
ALKJNCZNEOTEMP
|
7.7 | Kd | 55 | — | |
MQSCGRDOQBVIMP
|
7.6 | IC50 | 5 | — | |
JYRQCAFYZKCCBK
|
7.6 | Ki | 2 | — | |
NUBQSBJQEOZDKV
|
7.6 | IC50 | 2 | — | |
PUPCRRRSBUYJAD
|
7.6 | Ki | 44 | Yes | |
UTDAGOYVDYQGFI
|
7.6 | IC50 | 2 | — | |
XKFTZKGMDDZMJI
|
7.6 | Ki | 56 | — | |
VAISRJZBJKFESC
|
7.6 | IC50 | 2 | — | |
LBVKEEFIPBQIMD
|
7.5 | Ki | 27 | — | |
WBQBMMMQJSJEJT
|
7.5 | Ki | 4 | — | |
GLDSKRNGVVYJAB
|
7.5 | Kd | 16 | — | |
SGZZQKMOFHIDKW
|
7.5 | Kd | 13 | — | |
XKFTZKGMDDZMJI
|
7.5 | Kd | 64 | Yes | |
ZHAUVQVDFHILNB
|
7.5 | IC50 | 2 | — | |
SVXALMKNVZGHQH
|
7.5 | IC50 | 2 | — | |
HJHMZOIXHWLHQD
|
7.4 | IC50 | 2 | — | |
TUBXJQSNTKADJB
|
7.4 | IC50 | 5 | — | |
OOTYDAPLACFYPB
|
7.4 | IC50 | 2 | — | |
CFIBXVQLBVNOHW
|
7.4 | Ki | 64 | — | |
MCCCQFAOMZMZKE
|
7.4 | Ki | 52 | — | |
WHVFDYQCAMPLMS
|
7.4 | Ki | 20 | Yes | |
JOOXLOJCABQBSG
|
7.4 | Kd | 139 | — | |
ZKHQZMGFQLTDQH
|
7.4 | IC50 | 3 | — | |
FLZUCWYTAFZBMF
|
7.4 | IC50 | 2 | — | |
DUKPHDKHHJUGAK
|
7.3 | IC50 | 4 | — |