Target Details
| UniProt AC | Q05397 |
|---|---|
| Gene Symbol | PTK2 |
| Protein Name | Focal adhesion kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF21477 (FERM_C_FAK1) PF00373 (FERM_M) PF18038 (FERM_N_2) PF03623 (Focal_AT) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 325
- Clinical molecules 26
- Avg pChEMBL 6.99
KEGG Pathways (28)
- Amoebiasis
- Axon guidance
- Bacterial invasion of epithelial cells
- Cadherin signaling
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Efferocytosis
- Endocrine resistance
- ErbB signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Growth hormone synthesis, secretion and action
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Integrin signaling
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- PI3K-Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Small cell lung cancer
- Transcriptional misregulation in cancer
- VEGF signaling pathway
- Yersinia infection
Active Molecules (325)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WZHYYHVLAMIXKN
|
9.3 | IC50 | 2 | — | |
AZSAXICINIVCFK
|
9.3 | IC50 | 2 | — | |
LVLFSSZNAIKYCD
|
9.3 | IC50 | 19 | — | |
FBCYLDMQAGIHQR
|
9.2 | IC50 | 2 | — | |
FKCIIMYQSRTZNM
|
9.2 | IC50 | 2 | — | |
AWJVIOYPZZZYAX
|
9.2 | IC50 | 2 | — | |
UAFDWTTZIJTWGE
|
9.1 | IC50 | 2 | — | |
CRAIIXIGEFCHBX
|
9.0 | IC50 | 2 | — | |
BCSHRERPHLTPEE
|
9.0 | IC50 | 3 | — | |
JKXHCHABOHZRIC
|
9.0 | IC50 | 2 | — | |
QQWUGDVOUVUTOY
|
9.0 | Kd | 231 | Yes | |
FWLMVFUGMHIOAA
|
8.9 | IC50 | 26 | — | |
BGNMLKFHDPQLLJ
|
8.9 | IC50 | 2 | — | |
IGUBBWJDMLCRIK
|
8.8 | IC50 | 3 | — | |
MZDKLVOWGIOKTN
|
8.8 | IC50 | 80 | — | |
POJZIZBONPAWIV
|
8.8 | IC50 | 5 | — | |
MZKCTWNUCVKGCB
|
8.7 | IC50 | 9 | — | |
NZNRLSKYWIKFMQ
|
8.7 | IC50 | 3 | — | |
LHQWPYOYDRVMFI
|
8.7 | Ki | 21 | — | |
OEFWUILIMFIVSE
|
8.7 | IC50 | 2 | — | |
ZTOIRWCKMDSZQZ
|
8.7 | IC50 | 2 | — | |
SXMOIWLLBKAOGR
|
8.6 | IC50 | 2 | — | |
QUZLPRLQAANSNR
|
8.6 | IC50 | 3 | — | |
CAHNFGYWMWNXMR
|
8.6 | IC50 | 9 | — | |
BCSHRERPHLTPEE
|
8.5 | IC50 | 3 | — | |
OWRXHGAFWZFFCW
|
8.5 | Ki | 113 | — | |
MUVVMGFRHXQCRG
|
8.5 | Ki | 2 | — | |
NGHZDJWRZKYLSD
|
8.5 | IC50 | 2 | — | |
RVULLEYKHMQYRU
|
8.5 | IC50 | 2 | — | |
KAVPZFNKRGDVLL
|
8.4 | IC50 | 2 | — | |
MOAIIOFZEWYTIP
|
8.4 | IC50 | 3 | — | |
AILRADAXUVEEIR
|
8.4 | IC50 | 75 | — | |
COZPORUDEQRJMN
|
8.4 | IC50 | 3 | — | |
ZJDFSKSBQBPOSK
|
8.4 | IC50 | 24 | Yes | |
TVUWQDLBEOZVOU
|
8.3 | Ki | 41 | — | |
NOUVYWRJTCFRGO
|
8.2 | IC50 | 2 | — | |
QORBSYUFEAFSTK
|
8.2 | IC50 | 2 | — | |
SJMCNVUMRNUOKS
|
8.2 | IC50 | 2 | — | |
FLEAYYMORDPWAJ
|
8.2 | Ki | 90 | — | |
UYJNQQDJUOUFQJ
|
8.2 | IC50 | 68 | — | |
FLTLUXCGVBUQLQ
|
8.2 | IC50 | 3 | — | |
FIKPXCOQUIZNHB
|
8.2 | IC50 | 9 | — | |
RQTWMVOMNNMRAP
|
8.2 | IC50 | 3 | — | |
RYYNGWLOYLRZLK
|
8.1 | Ki | 104 | — | |
FLTLUXCGVBUQLQ
|
8.1 | IC50 | 3 | — | |
HMFCBYNYXTWSRZ
|
8.1 | IC50 | 2 | — | |
WFYYQQDXEBYUGQ
|
8.0 | IC50 | 2 | — | |
RPKOZPSDQJWXMG
|
8.0 | IC50 | 2 | — | |
WNNZZRWQUYRLFF
|
8.0 | IC50 | 2 | — | |
HESLKTSGTIBHJU
|
8.0 | IC50 | 6 | — |