Target Details
| UniProt AC | Q04206 |
|---|---|
| Gene Symbol | RELA |
| Protein Name | Transcription factor p65 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16179 (RHD_dimer) PF00554 (RHD_DNA_bind) |
Summary
- Multi-target molecules 134
- Clinical molecules 1
- Avg pChEMBL 6.97
KEGG Pathways (77)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Amoebiasis
- Antifolate resistance
- Apoptosis
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Cocaine addiction
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Diabetic cardiomyopathy
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Inflammatory bowel disease
- Influenza A
- Insulin resistance
- Kaposi sarcoma-associated herpesvirus infection
- Legionellosis
- Leishmaniasis
- Lipid and atherosclerosis
- Longevity regulating pathway
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prolactin signaling pathway
- Prostate cancer
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Transcriptional misregulation in cancer
- Tuberculosis
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
Associated Diseases (2)
Active Molecules (134)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CZKZWDJWVZTWCF
|
7.1 | IC50 | 3 | — | |
DAPAQENNNINUPW
|
7.1 | IC50 | 3 | — | |
XBHLVKXDYPBNDL
|
7.1 | IC50 | 3 | — | |
FUGLHOPHXOBFTJ
|
7.0 | IC50 | 3 | — | |
UJMDREBVAJFRRA
|
7.0 | IC50 | 3 | — | |
GEVKCFZCFWBZDR
|
7.0 | IC50 | 4 | — | |
BMEOHHZTHGXSLS
|
7.0 | IC50 | 5 | — | |
NKVHDZTUPQKDRT
|
7.0 | IC50 | 5 | — | |
KKWMXUXYPBDQQX
|
7.0 | IC50 | 3 | — | |
DDKULVADLPTYQQ
|
7.0 | IC50 | 4 | — | |
DPGQQXHQAVXKQK
|
7.0 | IC50 | 4 | — | |
WRWOBEULXQVZEU
|
6.9 | IC50 | 4 | — | |
UYPBWBVIEKACNK
|
6.9 | IC50 | 3 | — | |
ODFGLJQOCBLUPX
|
6.9 | IC50 | 3 | — | |
YOJHPSLHBFFDDL
|
6.9 | IC50 | 19 | — | |
XRASFZQHAQLDPI
|
6.8 | IC50 | 4 | — | |
PIRMAZILBVSDGM
|
6.8 | IC50 | 3 | — | |
JVOLOUHVFQIODG
|
6.8 | IC50 | 4 | — | |
AHRPMNUHBXZQDF
|
6.7 | IC50 | 5 | — | |
DWADBTCPCYEZHD
|
6.7 | IC50 | 5 | — | |
JTURLWVYGOCZPN
|
6.7 | IC50 | 4 | — | |
NVROPPGYYYTZRD
|
6.7 | IC50 | 5 | — | |
PTHWPWGFLGQPPP
|
6.7 | IC50 | 5 | — | |
QNZVBFMXWNWVKG
|
6.7 | IC50 | 3 | — | |
VNFBTPGRSWAUOB
|
6.7 | IC50 | 4 | — | |
WKVHCLGIAQDALT
|
6.7 | IC50 | 5 | — | |
AEJBRRNNGUXYFJ
|
6.7 | IC50 | 4 | — | |
OYFZNKYRLJYLLZ
|
6.7 | IC50 | 3 | — | |
PYZCQWBFZACXGV
|
6.7 | IC50 | 3 | — | |
LJXUCMUMFCNMRH
|
6.7 | IC50 | 3 | — | |
KZDKFOCZYHSMEC
|
6.6 | IC50 | 3 | — | |
NEQZWEXWOFPKOT
|
6.6 | IC50 | 9 | — | |
ZECWHQQHJLYWHX
|
6.6 | IC50 | 3 | — | |
SULRSFDRXHBJMJ
|
6.6 | IC50 | 3 | — | |
YLQURXFEXBORQH
|
6.5 | IC50 | 3 | — | |
AJSVZSXZWIFNMH
|
6.5 | IC50 | 4 | — | |
BQSQYQQCGHOGDS
|
6.5 | IC50 | 5 | — | |
CRDXILZNMTVNLW
|
6.5 | IC50 | 5 | — | |
CWMSEWLBVPSYON
|
6.5 | IC50 | 5 | — | |
DWVXJMXXTULGDP
|
6.5 | IC50 | 5 | — | |
HJAKTQAHKIJTKU
|
6.5 | IC50 | 5 | — | |
HYVDSMGJEYQZQA
|
6.5 | IC50 | 4 | — | |
IFSMLVGASIQEST
|
6.5 | IC50 | 4 | — | |
GWJBHUPUYXBCEZ
|
6.5 | IC50 | 4 | — | |
LNAGGZKCRWOROX
|
6.5 | IC50 | 3 | — | |
QPTGSCDYSIJKAL
|
6.5 | IC50 | 3 | — | |
MWKSRKSEWLRPBL
|
6.5 | Kd | 1075 | — | |
HMXLOKAIIPOWQP
|
6.4 | IC50 | 3 | — | |
BFANKIPRJRXYSS
|
6.4 | IC50 | 4 | — | |
ODRMXBSDOYWKNE
|
6.4 | IC50 | 4 | — |