Target Details
| UniProt AC | Q02750 |
|---|---|
| Gene Symbol | MAP2K1 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 543
- Clinical molecules 31
- Avg pChEMBL 7.3
KEGG Pathways (92)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (5)
Active Molecules (543)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ISLCYYCODRRXHY
|
6.7 | IC50 | 2 | — | |
NSDPPHUZHNFMPM
|
6.7 | IC50 | 2 | — | |
GFXDMBPHZFCKLA
|
6.7 | IC50 | 2 | — | |
ULGFNGZSEVQFRS
|
6.7 | IC50 | 2 | — | |
YSOXURBNXLFBCL
|
6.7 | IC50 | 3 | — | |
ZXRMCWVMPXUCJH
|
6.7 | IC50 | 3 | — | |
JPOHYOWEEKRRJK
|
6.6 | IC50 | 3 | — | |
OZZKFBLHUBAGEQ
|
6.6 | IC50 | 3 | — | |
RDHJQMGXZQRIBK
|
6.6 | IC50 | 2 | — | |
UVNRELDVCTVFNZ
|
6.6 | IC50 | 2 | — | |
SNGHTNLILPLJFU
|
6.6 | IC50 | 2 | — | |
ULERIKQXJLZMMV
|
6.6 | IC50 | 2 | — | |
YVFAWXDKCQRMPA
|
6.6 | IC50 | 3 | — | |
BOUKILWEXWLSRJ
|
6.6 | IC50 | 3 | — | |
HALXYXINRHRFCA
|
6.6 | IC50 | 2 | — | |
JJGSOVIZOMZMCS
|
6.6 | Ki | 35 | — | |
MASJMHFQMYAPJR
|
6.6 | Ki | 41 | — | |
PBBRWFOVCUAONR
|
6.6 | Ki | 26 | Yes | |
QFHRPRDSAHFZEG
|
6.6 | Ki | 6 | — | |
VKBFHTIUXUCYRQ
|
6.6 | Ki | 66 | — | |
VOSBQMIZOZZEBZ
|
6.6 | IC50 | 3 | — | |
WHWRHSZXRYNDDO
|
6.6 | IC50 | 8 | Yes | |
FJCQZSRKMFPCOW
|
6.6 | IC50 | 3 | — | |
KEEFYWUVYWZFPQ
|
6.6 | IC50 | 3 | — | |
NKWJABPDWZOARV
|
6.6 | IC50 | 3 | — | |
LTXXWWCTWJCQQL
|
6.6 | IC50 | 3 | — | |
BKWCDRNUXDVCQV
|
6.6 | IC50 | 3 | — | |
RXYXZBWUKQLVKR
|
6.6 | IC50 | 3 | — | |
IUEPNGJGSBBBHF
|
6.5 | IC50 | 3 | — | |
OXHGKUOZRLFONP
|
6.5 | IC50 | 3 | — | |
QHESHAOBGKRAPW
|
6.5 | IC50 | 2 | Yes | |
RQGOSNUBDGLIMT
|
6.5 | IC50 | 2 | — | |
JGXHQMQPGIDNQB
|
6.5 | IC50 | 3 | — | |
NOUNORLHGGWAFT
|
6.5 | IC50 | 2 | — | |
RNRYJOIXVZVCNT
|
6.5 | IC50 | 3 | — | |
ZCHZSBUNJOCWCW
|
6.5 | IC50 | 3 | — | |
AFPAJDOKDKWGGI
|
6.5 | IC50 | 3 | — | |
QXINTPBKWYTXMI
|
6.5 | IC50 | 2 | — | |
ZJZMAUBKRKIVPH
|
6.5 | IC50 | 3 | Yes | |
JMWYXCOECNESCH
|
6.5 | IC50 | 2 | — | |
MTLRPYAACHUORY
|
6.5 | IC50 | 3 | — | |
ZAVWKSRHQJXKLQ
|
6.5 | IC50 | 2 | — | |
NHHQJBCNYHBUSI
|
6.5 | Kd | 220 | — | |
NWMPVMMGSHXANZ
|
6.5 | Ki | 58 | — | |
PRRYQINUAIQTFJ
|
6.5 | Ki | 11 | — | |
GVQGUQGHCNFFBK
|
6.5 | IC50 | 2 | — | |
COTQMNHTEKDUSB
|
6.5 | IC50 | 3 | — | |
DAHOKVXQXIXZEY
|
6.5 | IC50 | 3 | — | |
NMPBUUSDUKCBEJ
|
6.5 | IC50 | 2 | — | |
NXSJMRCTGYTSTK
|
6.5 | Kd | 200 | — |