Target Details
| UniProt AC | Q02750 |
|---|---|
| Gene Symbol | MAP2K1 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 543
- Clinical molecules 31
- Avg pChEMBL 7.3
KEGG Pathways (92)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (5)
Active Molecules (543)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
COACPTNNJAFVAN
|
7.4 | IC50 | 2 | — | |
NRIBQLACPGHUAA
|
7.4 | IC50 | 2 | — | |
UAJHFQMFAUXIIV
|
7.3 | IC50 | 2 | — | |
FDGNZRIUKVKUPL
|
7.3 | IC50 | 2 | — | |
GFMMXOIFOQCCGU
|
7.3 | IC50 | 4 | — | |
XTHVWVXPQFNIMZ
|
7.3 | IC50 | 2 | — | |
GPQZSOKVRXFLTO
|
7.3 | IC50 | 3 | — | |
GTCQTDKQZUQUNF
|
7.3 | IC50 | 2 | — | |
LIPYYLYUPRIGII
|
7.3 | IC50 | 2 | — | |
XLNYFDGIIRQJMP
|
7.3 | IC50 | 3 | — | |
YFTFYHQYNHSUKH
|
7.3 | IC50 | 2 | — | |
RUGZAGYYZGVWBZ
|
7.3 | IC50 | 3 | — | |
SZWMQRVECIKICL
|
7.3 | IC50 | 3 | — | |
MBLVLWZXURYDFW
|
7.3 | IC50 | 3 | — | |
UPUBHFBOYYXILS
|
7.3 | IC50 | 3 | — | |
IFPPYSWJNWHOLQ
|
7.3 | Ki | 52 | Yes | |
MWUFVYLAWAXDHQ
|
7.3 | IC50 | 2 | — | |
OIEYGVGFYHDQFP
|
7.3 | IC50 | 3 | — | |
VCFDMLBPASGZTP
|
7.3 | Ki | 38 | — | |
MFAQYJIYDMLAIM
|
7.3 | Kd | 130 | Yes | |
BKMQVXMXPSFWIB
|
7.3 | IC50 | 3 | — | |
FBNWZJDFKJOJGI
|
7.3 | IC50 | 2 | — | |
NEHSGKZSBWLRCZ
|
7.3 | IC50 | 3 | — | |
OYAMULIHRWEUAR
|
7.3 | IC50 | 7 | Yes | |
UORAPQCBWYIISR
|
7.3 | Kd | 15 | — | |
UORAPQCBWYIISR
|
7.3 | Kd | 13 | — | |
WECQTIGBRIQMEY
|
7.3 | IC50 | 2 | — | |
KWSIGBRAMTYPHR
|
7.3 | IC50 | 3 | — | |
OGFOENLUWIJPAQ
|
7.3 | IC50 | 3 | — | |
XKJZAXRHJJVTOB
|
7.3 | IC50 | 3 | — | |
IOYRVIKODRKVSN
|
7.2 | IC50 | 3 | — | |
PLWVNCSSFNLWHM
|
7.2 | IC50 | 3 | — | |
RSMXRBHNKITPCM
|
7.2 | IC50 | 2 | — | |
DUKJABPGWUISRC
|
7.2 | IC50 | 10 | — | |
FYVWDSXUBVIRLZ
|
7.2 | IC50 | 3 | — | |
MOBJWMLIEWEQFK
|
7.2 | IC50 | 2 | — | |
MWKSRKSEWLRPBL
|
7.2 | Kd | 1075 | — | |
MIEMMRMSQFJRGZ
|
7.2 | IC50 | 2 | — | |
POTXSYBBGGTEDA
|
7.2 | IC50 | 2 | — | |
CIAWTKNWINEPQJ
|
7.2 | IC50 | 2 | — | |
FXXREISGAMJGMI
|
7.2 | IC50 | 2 | — | |
OCMLTNFXMKEHJW
|
7.2 | IC50 | 2 | — | |
OTUVOFAIBFSMKE
|
7.2 | IC50 | 3 | — | |
QJRCOIYPHTWFQW
|
7.2 | IC50 | 3 | — | |
OWRXHGAFWZFFCW
|
7.2 | Ki | 113 | — | |
IWUMUNQLJUUETN
|
7.2 | IC50 | 3 | — | |
LWCIFTBBROCMKF
|
7.2 | IC50 | 2 | — | |
BVZSCIBPDJIGSJ
|
7.2 | IC50 | 2 | — | |
MSWUJKZTIFJSKD
|
7.2 | IC50 | 3 | — | |
YJSFAHMGDRBZGH
|
7.2 | IC50 | 16 | Yes |