Target Details
| UniProt AC | Q02750 |
|---|---|
| Gene Symbol | MAP2K1 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 543
- Clinical molecules 31
- Avg pChEMBL 7.3
KEGG Pathways (92)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (5)
Active Molecules (543)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QHNDLISOJCGFBM
|
8.1 | IC50 | 3 | — | |
YKYFNNNNXYBCDU
|
8.1 | IC50 | 3 | — | |
WUOCHAVLTKNGCC
|
8.1 | IC50 | 2 | — | |
GSLOARSKTZJLMH
|
8.1 | IC50 | 2 | — | |
HTHDXKQVWMYVAF
|
8.1 | IC50 | 2 | — | |
ORBLOJJZDLUQDF
|
8.1 | IC50 | 4 | — | |
FIMYFEGKMOCQKT
|
8.1 | Kd | 3 | — | |
ABSKEGXPTPLQJU
|
8.1 | IC50 | 2 | — | |
BQYYPCSULGHPTA
|
8.1 | IC50 | 2 | — | |
GSVIQADQNZROAL
|
8.1 | IC50 | 2 | — | |
HDAJDNHIBCDLQF
|
8.1 | IC50 | 4 | — | |
HEVHEWAKLRICCA
|
8.1 | IC50 | 3 | — | |
NUTGQSGXRGUYMD
|
8.1 | IC50 | 2 | — | |
WBARVJREQICCOV
|
8.1 | IC50 | 2 | — | |
JDNOQPFAYAAWAA
|
8.0 | IC50 | 2 | — | |
MENPTCWEPFMOHL
|
8.0 | IC50 | 3 | — | |
PJMVKCSXHOGMAD
|
8.0 | IC50 | 2 | — | |
ZLHOIUNYCFOMBY
|
8.0 | IC50 | 2 | — | |
QXQGHCJUTRTRLJ
|
8.0 | IC50 | 2 | — | |
GRZCUOLWBQKOEY
|
8.0 | IC50 | 3 | — | |
GZEKNZXQCOKIPI
|
8.0 | IC50 | 3 | — | |
MAEIMZUQBHFKFG
|
8.0 | IC50 | 3 | — | |
RVJWNYACFZPAEW
|
8.0 | IC50 | 2 | — | |
XCQCCPWWWPXVFG
|
8.0 | IC50 | 2 | — | |
XZXHXSATPCNXJR
|
8.0 | Kd | 165 | Yes | |
YFTDOISNXAUTKI
|
8.0 | IC50 | 2 | — | |
ZDACFCFMMWTLTA
|
8.0 | IC50 | 9 | — | |
BNEIJRJUSPJYIW
|
8.0 | IC50 | 2 | — | |
DVSZEHUFBBJQKJ
|
8.0 | IC50 | 3 | — | |
LMUOLSXKQCWLAY
|
8.0 | IC50 | 2 | — | |
NGMAFXVXLJNKNC
|
8.0 | IC50 | 3 | — | |
NISGOINEQGAHOU
|
8.0 | IC50 | 2 | — | |
SGCQOTWECLPFOA
|
8.0 | IC50 | 3 | — | |
UMHJHEYJBGFPDL
|
8.0 | IC50 | 2 | — | |
WBAHMOJHMNNARC
|
8.0 | IC50 | 2 | — | |
ZHSZRLNZUKRCPI
|
8.0 | IC50 | 2 | — | |
ACWZRVQXLIRSDF
|
7.9 | IC50 | 2 | — | |
CBVUTXWXSYHWDW
|
7.9 | IC50 | 3 | — | |
CXQHYVUVSFXTMY
|
7.9 | Kd | 154 | — | |
SEJGTFPOEJWEGG
|
7.9 | Kd | 149 | — | |
VVIXOXWAEFXJFE
|
7.9 | IC50 | 2 | — | |
YRKLUPVSKKKSFY
|
7.9 | IC50 | 3 | — | |
DNFMTAJPYCSJJR
|
7.9 | IC50 | 3 | — | |
FQTDEACKAXRSFD
|
7.9 | IC50 | 2 | — | |
KVLZSRGASWOICS
|
7.9 | IC50 | 3 | — | |
OZMFPIJIZRXMPR
|
7.9 | IC50 | 3 | — | |
QUBGEHFUYLWZSU
|
7.9 | IC50 | 3 | — | |
TUFUIJMKGKKREO
|
7.9 | IC50 | 2 | — | |
VYFAUKUIHFXSHR
|
7.9 | IC50 | 2 | — | |
XJDANWRYPRBMQG
|
7.9 | IC50 | 3 | — |