Target Details
| UniProt AC | Q02750 |
|---|---|
| Gene Symbol | MAP2K1 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 543
- Clinical molecules 31
- Avg pChEMBL 7.3
KEGG Pathways (92)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (5)
Active Molecules (543)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KYTNOWSUXYPQTJ
|
6.2 | IC50 | 2 | — | |
ODMQDVGOBAKLFG
|
6.1 | IC50 | 2 | — | |
QDXQGTXUKDYEBI
|
6.1 | IC50 | 3 | — | |
UORAPQCBWYIISR
|
6.1 | Kd | 12 | — | |
AUDNGNGLLRZLDR
|
6.1 | Ki | 33 | — | |
NFKACFNEFTYTHG
|
6.1 | IC50 | 2 | — | |
QKUFEXGLTQADSA
|
6.1 | Ki | 5 | — | |
SEZFNTZQMWJIAI
|
6.1 | Ki | 22 | — | |
UIRCQOKSJDLYBB
|
6.1 | Ki | 50 | — | |
WAKGEHXTOOFEAE
|
6.1 | Ki | 27 | — | |
YUYWSKXPXLUJNA
|
6.1 | IC50 | 2 | — | |
YYPKOMNJRZRWIC
|
6.1 | Ki | 26 | — | |
JEIJQBSAHGKSHC
|
6.1 | IC50 | 3 | — | |
JYRJOQGKGMHTOO
|
6.1 | IC50 | 9 | — | |
VAARYSWULJUGST
|
6.1 | Kd | 119 | Yes | |
JYRJOQGKGMHTOO
|
6.1 | IC50 | 11 | — | |
KKORZXWRRHLIMN
|
6.1 | IC50 | 3 | — | |
REJHULCFUPQXSV
|
6.0 | IC50 | 2 | — | |
HIASHEATKNRFJC
|
6.0 | IC50 | 2 | Yes | |
MKMYAVUUMSCFQQ
|
6.0 | IC50 | 4 | Yes | |
RJUNTBXDFOQXLU
|
6.0 | IC50 | 2 | — | |
DKZYXHCYPUVGAF
|
6.0 | Kd | 112 | — | |
UVBKNBPCVRBUTF
|
6.0 | IC50 | 5 | — | |
BRTHUECZMVKNMQ
|
6.0 | Ki | 31 | — | |
BSBQPLUISHJULY
|
6.0 | IC50 | 11 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
JBRASADWXDKCLJ
|
6.0 | Ki | 22 | — | |
JNXJKTXDSPWNRP
|
6.0 | Ki | 30 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
KUNZDWIFPOMUOX
|
6.0 | Ki | 36 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — | |
MCKPYPWHBUXLEZ
|
6.0 | Ki | 21 | — | |
MMFBBQQGBVPLQQ
|
6.0 | Ki | 13 | — | |
MTQIPTSHULBJPD
|
6.0 | IC50 | 2 | — | |
NECQZMQPXFYVOY
|
6.0 | Ki | 26 | — | |
RTYJMUXLFRYRBU
|
6.0 | Ki | 35 | — | |
UHTHHESEBZOYNR
|
6.0 | Ki | 66 | Yes | |
WIZFHSAFKKUPRU
|
6.0 | Ki | 5 | — | |
XTVULKIROSNNTG
|
6.0 | Ki | 29 | — | |
XZWVOUQIYLZUCJ
|
6.0 | Ki | 23 | — | |
YXUQWISLOFXNGN
|
6.0 | Ki | 16 | — | |
ZBNZXTGUTAYRHI
|
6.0 | Kd | 102 | Yes | |
ZDPGLLQANLROFM
|
6.0 | Ki | 17 | — |