Target Details
| UniProt AC | Q02750 |
|---|---|
| Gene Symbol | MAP2K1 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 543
- Clinical molecules 31
- Avg pChEMBL 7.3
KEGG Pathways (92)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (5)
Active Molecules (543)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RWVYUXIOUYZPHM
|
6.5 | IC50 | 2 | — | |
REOWJUIZCQXSQH
|
6.5 | IC50 | 3 | — | |
VCXKYIYUQGZFAQ
|
6.5 | IC50 | 2 | — | |
PKCDDUHJAFVJJB
|
6.5 | Kd | 13 | — | |
VAPPIXLSHDYSCY
|
6.5 | IC50 | 3 | — | |
WLGLAXWJUWQYEQ
|
6.5 | IC50 | 3 | — | |
VOURFPDYANCOLP
|
6.4 | IC50 | 3 | — | |
WVUNYSQLFKLYNI
|
6.4 | Kd | 46 | Yes | |
GUGQTZDITULCAM
|
6.4 | IC50 | 3 | — | |
OGTULHQQFZVXGB
|
6.4 | IC50 | 3 | — | |
AEYLJTAIDDIOBA
|
6.4 | Ki | 53 | — | |
DFMCXVONDDGQIY
|
6.4 | Ki | 66 | — | |
FENWEVRRFMFDBS
|
6.4 | IC50 | 2 | — | |
NVRXTLZYXZNATH
|
6.4 | Ki | 47 | Yes | |
QBKUOOQFSVMDPB
|
6.4 | Ki | 31 | — | |
RXVJKLFGWMBSIF
|
6.4 | IC50 | 4 | — | |
URNZTLZSAVLTIZ
|
6.4 | Ki | 26 | — | |
ZBYGBITZFKOQTA
|
6.4 | Ki | 18 | — | |
DSKCFNMBWKCOQW
|
6.4 | IC50 | 2 | — | |
OSVUGUHRKMMBSE
|
6.4 | Kd | 170 | — | |
RZANYPMIIMRZPZ
|
6.4 | IC50 | 2 | — | |
UJLAWZDWDVHWOW
|
6.4 | Kd | 16 | — | |
WYURAYNXEQDFHF
|
6.3 | IC50 | 2 | — | |
YHATZJNTNYXLOB
|
6.3 | IC50 | 3 | — | |
ZLXAJCRRJPLBTQ
|
6.3 | IC50 | 2 | — | |
JDBMWHCBKTXEIL
|
6.3 | IC50 | 3 | — | |
KYJAPJCTKKWSCJ
|
6.3 | IC50 | 2 | — | |
NQEXMKXQXCYPRH
|
6.3 | IC50 | 2 | — | |
TVOFCCIKXFMAKW
|
6.3 | IC50 | 3 | — | |
ATGVCJYHNOSZEV
|
6.3 | Ki | 23 | — | |
BLQYVHBZHAISJM
|
6.3 | Ki | 54 | — | |
CFOIDJZBUPNXCH
|
6.3 | IC50 | 2 | — | |
JZTOUVBEZONDKA
|
6.3 | Ki | 80 | — | |
VSVWQTDDGQSGHP
|
6.3 | Ki | 51 | — | |
VTQQYBGURNVVFE
|
6.3 | Ki | 17 | — | |
WQFGNANQTYLQBP
|
6.3 | Ki | 16 | — | |
MCYLFIQEUTZASW
|
6.3 | IC50 | 2 | — | |
PIQCTGMSNWUMAF
|
6.3 | Kd | 137 | Yes | |
YYLKKYCXAOBSRM
|
6.3 | Kd | 191 | — | |
INYSELGLAAADNH
|
6.3 | IC50 | 3 | — | |
YVSXASJEPXDDQH
|
6.3 | IC50 | 2 | — | |
CJQGLUJHMXCLQY
|
6.3 | IC50 | 11 | — | |
QQWUGDVOUVUTOY
|
6.3 | Kd | 231 | Yes | |
YZDJQTHVDDOVHR
|
6.3 | Kd | 23 | — | |
GWKDRZYNFAKCFG
|
6.2 | IC50 | 2 | — | |
HQTKAIDPYRFHMI
|
6.2 | IC50 | 3 | — | |
HZJDBCYRQSJNLZ
|
6.2 | Ki | 7 | — | |
PXRDIWAVNLQFBI
|
6.2 | IC50 | 6 | Yes | |
QVNZKVACBBTKSL
|
6.2 | Ki | 38 | — | |
KZZVDCJDNUXICL
|
6.2 | IC50 | 2 | — |