Target Details
| UniProt AC | Q02750 |
|---|---|
| Gene Symbol | MAP2K1 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 543
- Clinical molecules 31
- Avg pChEMBL 7.3
KEGG Pathways (92)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (5)
Active Molecules (543)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SUDAHWBOROXANE
|
9.1 | IC50 | 2 | — | |
GSSSJMXLSDAINU
|
9.0 | IC50 | 3 | — | |
MRONWWYUJGYEFK
|
9.0 | IC50 | 3 | — | |
QVWPYLHQPCBEIN
|
9.0 | IC50 | 2 | — | |
TXRDPXPHKUXGQL
|
9.0 | IC50 | 3 | — | |
XXSSGBYXSKOLAM
|
8.8 | IC50 | 2 | — | |
HBRLHEXMNQENQM
|
8.8 | IC50 | 2 | — | |
DDKYUKCNWXPYNZ
|
8.8 | IC50 | 2 | — | |
PIZSULWGRRPCLE
|
8.7 | IC50 | 2 | — | |
GFOXCTULQRSDEP
|
8.7 | IC50 | 3 | — | |
GQAZGSHVSAGDOJ
|
8.7 | IC50 | 2 | — | |
HTBCCQAFXXDNPH
|
8.7 | IC50 | 2 | — | |
NEQZWEXWOFPKOT
|
8.7 | IC50 | 9 | Yes | |
NJSXKZAXYUNSFP
|
8.7 | IC50 | 3 | — | |
OHRLRWVLPBHNJE
|
8.7 | IC50 | 3 | — | |
OUMIJVSXUWJOFJ
|
8.7 | IC50 | 2 | — | |
QSENMPAGYMUVDE
|
8.7 | IC50 | 5 | — | |
UTEIFOJYUWWJFJ
|
8.7 | IC50 | 3 | — | |
WHQSHUVXTQTMMK
|
8.7 | IC50 | 2 | — | |
XLXDRLLBZCUGME
|
8.7 | IC50 | 3 | — | |
LIRYPHYGHXZJBZ
|
8.7 | IC50 | 2 | — | |
TXIMPIPUCIORFP
|
8.6 | IC50 | 2 | — | |
HXDYCEVDYKSUGB
|
8.6 | IC50 | 2 | — | |
MMDRIRJGXNRLBH
|
8.6 | IC50 | 2 | — | |
SOLZIGXKXMEQFO
|
8.6 | IC50 | 2 | — | |
XVCILAYDBYHBID
|
8.6 | IC50 | 2 | — | |
ATBAETXFFCOZOY
|
8.5 | IC50 | 3 | — | |
AXHWESODWDIJCC
|
8.5 | IC50 | 2 | — | |
KXEFWEJDWLGBJH
|
8.5 | IC50 | 3 | — | |
MBCDKSSXEBSIEN
|
8.5 | IC50 | 2 | — | |
PXIZVJMPZWPXFU
|
8.5 | IC50 | 2 | — | |
QNTGJAKMNSBSBC
|
8.5 | IC50 | 3 | — | |
RCLQNICOARASSR
|
8.5 | IC50 | 2 | — | |
VIUAUNHCRHHYNE
|
8.5 | IC50 | 3 | — | |
UIARLYUEJFELEN
|
8.5 | Kd | 289 | Yes | |
RFBRRBJZDPRBES
|
8.4 | IC50 | 2 | — | |
ZCCPLJOKGAACRT
|
8.4 | Kd | 599 | — | |
ARLNFRRAHKLWMT
|
8.4 | IC50 | 2 | — | |
GTKJOUZHAZVXFH
|
8.4 | IC50 | 2 | — | |
HTYIISVKUAGYRR
|
8.4 | IC50 | 2 | — | |
MEMXIDIPZZGONE
|
8.4 | IC50 | 3 | — | |
MZRCKIBDAXSKTH
|
8.4 | IC50 | 3 | — | |
UAFZNGTVQDQROK
|
8.4 | IC50 | 3 | — | |
YHAJJCOJWJKFSB
|
8.4 | IC50 | 2 | — | |
YLQUXDOVSUUPRE
|
8.4 | IC50 | 3 | — | |
BSMCAPRUBJMWDF
|
8.4 | IC50 | 4 | — | |
WYKQRLRSJYQMOK
|
8.4 | IC50 | 2 | — | |
ZACDXTRJHVRWDV
|
8.4 | IC50 | 2 | — | |
UBPYILGKFZZVDX
|
8.4 | IC50 | 130 | Yes | |
HLZILPFHOWGJFB
|
8.3 | IC50 | 2 | — |