Target Details
| UniProt AC | Q01668 |
|---|---|
| Gene Symbol | CACNA1D |
| Protein Name | Voltage-dependent L-type calcium channel subunit alpha-1D |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF08763 (Ca_chan_IQ) PF16885 (CAC1F_C) PF16905 (GPHH) PF00520 (Ion_trans) |
Summary
- Multi-target molecules 117
- Clinical molecules 4
- Avg pChEMBL 7.81
KEGG Pathways (35)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amphetamine addiction
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Carbohydrate digestion and absorption
- Cardiac muscle contraction
- Cellular senescence
- Chemical carcinogenesis - receptor activation
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- GABAergic synapse
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hypertrophic cardiomyopathy
- Insulin secretion
- MAPK signaling pathway
- Oxytocin signaling pathway
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Renin secretion
- Retrograde endocannabinoid signaling
- Serotonergic synapse
- Tight junction
- Type II diabetes mellitus
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (2)
Active Molecules (117)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
GALCSZPFCCZIBC
|
6.5 | IC50 | 20 | Yes | |
HBNPJJILLOYFJU
|
6.5 | IC50 | 21 | — | |
NZSMHVGBSNDKDO
|
6.5 | IC50 | 4 | — | |
DXHGSDDDNQXAEJ
|
6.4 | IC50 | 26 | — | |
HKKFCFIFPDLOKD
|
6.3 | IC50 | 4 | — | |
SKVXOYIMICHFPV
|
6.3 | IC50 | 10 | Yes | |
HSUGRBWQSSZJOP
|
6.2 | IC50 | 5 | — | |
UYZIPLMTFSGKAJ
|
6.2 | IC50 | 5 | — | |
CGEFSAWBLMCMJR
|
6.2 | IC50 | 4 | — | |
RVBQIBMRQBVLMH
|
6.2 | IC50 | 4 | — | |
CVFBVSUFNWOPLD
|
6.1 | IC50 | 6 | — | |
XKDFZZUFCHOVRN
|
6.1 | IC50 | 27 | — | |
NFBNIRNKYJTDIE
|
6.1 | IC50 | 16 | Yes | |
SAFUGOIRFHJACA
|
6.0 | IC50 | 4 | — | |
GUGOEEXESWIERI
|
6.0 | IC50 | 18 | Yes | |
KYAGVGRXHALGSE
|
6.0 | IC50 | 5 | — | |
UIEATEWHFDRYRU
|
6.0 | IC50 | 8 | — |