Target Details
| UniProt AC | Q01668 |
|---|---|
| Gene Symbol | CACNA1D |
| Protein Name | Voltage-dependent L-type calcium channel subunit alpha-1D |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF08763 (Ca_chan_IQ) PF16885 (CAC1F_C) PF16905 (GPHH) PF00520 (Ion_trans) |
Summary
- Multi-target molecules 117
- Clinical molecules 4
- Avg pChEMBL 7.81
KEGG Pathways (35)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amphetamine addiction
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Carbohydrate digestion and absorption
- Cardiac muscle contraction
- Cellular senescence
- Chemical carcinogenesis - receptor activation
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- GABAergic synapse
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hypertrophic cardiomyopathy
- Insulin secretion
- MAPK signaling pathway
- Oxytocin signaling pathway
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Renin secretion
- Retrograde endocannabinoid signaling
- Serotonergic synapse
- Tight junction
- Type II diabetes mellitus
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (2)
Active Molecules (117)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HYIMSNHJOBLJNT
|
7.8 | IC50 | 6 | — | |
NOCIOWGNSBLDHC
|
7.8 | IC50 | 26 | — | |
NWSFHJWTWBRJFA
|
7.8 | IC50 | 26 | — | |
NVLFDWLIOVSYAF
|
7.8 | IC50 | 4 | — | |
UJPHXNFMWVCEBX
|
7.8 | IC50 | 4 | — | |
CLSLOWKHEUDMRP
|
7.7 | IC50 | 26 | — | |
RKTLPLNLALGPKT
|
7.7 | Ki | 4 | — | |
ZTNBOUBFOFURTR
|
7.6 | IC50 | 26 | — | |
BDMBSHGVIWYMFZ
|
7.6 | IC50 | 26 | — | |
LFBPUPJLIZDNMB
|
7.6 | IC50 | 4 | — | |
ZVUQWPQXEDQMQO
|
7.6 | IC50 | 4 | — | |
BDZDJFPQRUGPOF
|
7.5 | IC50 | 26 | — | |
BVNRYPXFJUABAB
|
7.5 | IC50 | 26 | — | |
KHNYTFYQPKVXKP
|
7.5 | Ki | 4 | — | |
NRQIYYZXZYUWFB
|
7.5 | IC50 | 26 | — | |
VLKBVXIFTQLGCO
|
7.5 | IC50 | 26 | — | |
MVUOEDQURQKALH
|
7.5 | IC50 | 26 | — | |
PSVKDIGKMXLUQF
|
7.5 | IC50 | 26 | — | |
IXSXSOMMKYUETH
|
7.5 | IC50 | 26 | — | |
KNZXTLGWVGHSPA
|
7.5 | Ki | 4 | — | |
FFLKWIPCJQAAJX
|
7.4 | IC50 | 26 | — | |
IYDRYGWSROLZSY
|
7.4 | Ki | 4 | — | |
QRGMHEOPAKSEPT
|
7.4 | IC50 | 26 | — | |
UMDPFCNSBNGNBU
|
7.4 | IC50 | 26 | — | |
QWTOYMMBYIZUDZ
|
7.4 | IC50 | 26 | — | |
NMUYSGNBSUTZOC
|
7.3 | IC50 | 4 | — | |
ZWJKOWFFHJCZRL
|
7.3 | IC50 | 26 | — | |
XNUZTIQWJMXUHN
|
7.2 | IC50 | 26 | — | |
DTPINYZLNUJBJO
|
7.2 | Ki | 4 | — | |
AZSLSVQTOKQPLV
|
7.2 | IC50 | 26 | — | |
CHDZSBDHFQDYBD
|
7.1 | Ki | 4 | — | |
BQQHWRLQVWTKDU
|
7.1 | IC50 | 26 | — | |
QKEPYKVCOWFCDP
|
7.1 | IC50 | 26 | — | |
YFOFVZPUHCDYSB
|
7.1 | IC50 | 4 | — | |
RTFHWULQHQDWPK
|
7.0 | IC50 | 26 | — | |
OKGUKEIPHKTCKR
|
7.0 | IC50 | 4 | — | |
KFBQDAJEXXORSH
|
6.9 | IC50 | 4 | — | |
CYYZSIFPMQWUQM
|
6.9 | IC50 | 4 | — | |
FOBFICSYUINKAA
|
6.9 | IC50 | 6 | — | |
HPTXPZUMVHDFCW
|
6.8 | IC50 | 4 | — | |
CCSNTESBCKUCEA
|
6.8 | IC50 | 4 | — | |
IGTBNUVMBDYPQG
|
6.8 | Ki | 8 | — | |
PTQTUHGWGGIJET
|
6.8 | Ki | 4 | — | |
SGTNSNPWRIOYBX
|
6.7 | IC50 | 19 | — | |
YVUQSNJEYSNKRX
|
6.7 | IC50 | 36 | — | |
RJHIEGFHLJUYSA
|
6.7 | IC50 | 5 | — | |
FLNYLINBEZROPL
|
6.6 | IC50 | 6 | — | |
NXCFKLLOEZTCHO
|
6.6 | Ki | 4 | — | |
IYIKLHRQXLHMJQ
|
6.6 | IC50 | 18 | — | |
RGUQEIQNPDMTLR
|
6.6 | IC50 | 4 | — |