Target Details
| UniProt AC | Q01668 |
|---|---|
| Gene Symbol | CACNA1D |
| Protein Name | Voltage-dependent L-type calcium channel subunit alpha-1D |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF08763 (Ca_chan_IQ) PF16885 (CAC1F_C) PF16905 (GPHH) PF00520 (Ion_trans) |
Summary
- Multi-target molecules 117
- Clinical molecules 4
- Avg pChEMBL 7.81
KEGG Pathways (35)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amphetamine addiction
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Carbohydrate digestion and absorption
- Cardiac muscle contraction
- Cellular senescence
- Chemical carcinogenesis - receptor activation
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- GABAergic synapse
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hypertrophic cardiomyopathy
- Insulin secretion
- MAPK signaling pathway
- Oxytocin signaling pathway
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Renin secretion
- Retrograde endocannabinoid signaling
- Serotonergic synapse
- Tight junction
- Type II diabetes mellitus
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (2)
Active Molecules (117)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KTPUGBNEQXUNRV
|
11.0 | IC50 | 4 | — | |
UHFNTHXCIOXLFJ
|
10.9 | IC50 | 4 | — | |
OSCYLUQUDCIHGJ
|
10.8 | IC50 | 4 | — | |
JLRNPSMEKJAHJA
|
10.8 | IC50 | 4 | — | |
FBMLVNDXALQUNW
|
10.7 | IC50 | 4 | — | |
DCZKYOPFILCJIP
|
10.6 | IC50 | 4 | — | |
NREREUAMJGGNIM
|
10.5 | IC50 | 4 | — | |
MSMPZIUSOLTPEU
|
10.5 | IC50 | 4 | — | |
RZJSTKKJVDYIOA
|
10.3 | IC50 | 4 | — | |
ITAOFSSOVNYZCS
|
10.3 | IC50 | 4 | — | |
HAUSPSIZKPPOQS
|
10.3 | IC50 | 4 | — | |
RDJPOCSFSZJJMV
|
9.8 | IC50 | 4 | — | |
YGODTRTXGSNAQE
|
9.6 | IC50 | 4 | — | |
UXOKIKTXYVUMOP
|
9.4 | IC50 | 4 | — | |
PVHUJELLJLJGLN
|
9.2 | IC50 | 5 | — | |
IMZDPHIRNMFYEE
|
8.8 | IC50 | 4 | — | |
ZDUFPHWRWAGROF
|
8.8 | IC50 | 4 | — | |
MNQUJICKNQOWHX
|
8.8 | IC50 | 4 | — | |
TWUDJPWCVJDVTM
|
8.7 | IC50 | 26 | — | |
CQCHOVDIAHVBMQ
|
8.7 | IC50 | 26 | — | |
MNQUJICKNQOWHX
|
8.7 | IC50 | 4 | — | |
SLHXCJDHRACRDL
|
8.6 | IC50 | 4 | — | |
LQNBSHGSEOTYDZ
|
8.6 | IC50 | 26 | — | |
PXSFEJMJKYVWBB
|
8.6 | IC50 | 4 | — | |
UUWBLIXLGUCSAG
|
8.6 | IC50 | 4 | — | |
ICJDZRKVAKAOCS
|
8.6 | IC50 | 4 | — | |
TYXGRJPOMQEXJV
|
8.5 | IC50 | 26 | — | |
GTVKXVAXHKIMQX
|
8.5 | IC50 | 26 | — | |
UQDUODRSYJTCBO
|
8.5 | IC50 | 4 | — | |
WQYRJJHWYTWPPG
|
8.4 | IC50 | 4 | — | |
GODISNLWEDTPGJ
|
8.4 | IC50 | 4 | — | |
YKNGHCPXBSRJAV
|
8.3 | IC50 | 4 | — | |
HACCLYCGUNUBJY
|
8.2 | IC50 | 26 | — | |
FRGPFJVINLDQIJ
|
8.2 | IC50 | 26 | — | |
JWZPZXKJEUAZFV
|
8.2 | IC50 | 26 | — | |
RIAAESBLPRZGAK
|
8.2 | IC50 | 26 | — | |
AJCGCPQKWYQPNQ
|
8.1 | IC50 | 26 | — | |
DAMJJTRLEZYXQM
|
8.1 | IC50 | 26 | — | |
XQLWNAFCTODIRK
|
8.1 | IC50 | 4 | — | |
QUYJROSEXGBONG
|
8.1 | IC50 | 26 | — | |
OXIUFIQCDNTAED
|
8.1 | IC50 | 26 | — | |
YEOAYGDVMJPHGG
|
8.0 | IC50 | 26 | — | |
OSYITGFTDTWGJW
|
8.0 | IC50 | 26 | — | |
IDBHHAZJRAVAIA
|
8.0 | IC50 | 4 | — | |
UGCISYLUHGKJKT
|
8.0 | IC50 | 26 | — | |
SRGBARMXFGWMTF
|
7.9 | IC50 | 26 | — | |
CNCRGRBWUATVCP
|
7.8 | IC50 | 26 | — | |
IXIXBYHIWIUFLB
|
7.8 | IC50 | 4 | — | |
YZIYDQGNWSHQSD
|
7.8 | IC50 | 26 | — | |
ZMYGBEMRHGJETO
|
7.8 | IC50 | 26 | — |