Target Details
UniProt ACP78536
Gene SymbolADAM17
Protein NameDisintegrin and metalloproteinase domain-containing protein 17
OrganismHomo sapiens
Entry Name
Organism Category Human
Pfam Domains PF16698 (ADAM17_MPD) PF00200 (Disintegrin) PF13574 (Reprolysin_2)
UniProt
Summary
  • Multi-target molecules 785
  • Clinical molecules 566
  • Avg pChEMBL 7.43
KEGG Pathways (6)
Associated Diseases (2)
Top Co-occurrence Targets
Active Molecules (785)
InChIKey pChEMBL Type Targets Clinical
JBVXKMHBLNDBBV 7.3 IC50 6 Yes
GSWRTFGMHRKLKT 7.3 IC50 14 Yes
IEFFRLNSCQIVBY 7.3 Ki 5 Yes
JSVQSOCCWRHOES 7.3 IC50 3 —
NVJUVGMOOGFJLZ 7.3 Ki 5 Yes
WEQCLTHHZZNFDV 7.3 Ki 6 Yes
MAPLEBZZVBOXKC 7.2 Ki 3 Yes
MLRVULAXCZJAAN 7.2 IC50 5 Yes
VMRNKHLEOQDUMJ 7.2 IC50 2 —
FJRQWHSKVHCEKG 7.2 IC50 4 Yes
LNMKFTOPZCDAED 7.2 IC50 4 Yes
QTXVPJOTKLUYMQ 7.2 IC50 5 —
XNLVNQQMTWGGIM 7.2 IC50 5 Yes
ASLUWSDEBRNVJV 7.2 IC50 6 Yes
WMJKIJLFVOMJDF 7.2 IC50 6 Yes
GVLVYQFIEXXQOS 7.2 IC50 3 Yes
HFCXLBPJFPHTAN 7.2 Ki 7 Yes
IMWYAYZRQVPCBO 7.2 IC50 2 Yes
KBRVEWFSDCONMH 7.2 IC50 3 Yes
BLVHWPCGFOTRGU 7.2 IC50 5 Yes
CBKKHHSQVZVIBM 7.2 IC50 6 Yes
CBVWAXQRTCTDDH 7.2 IC50 2 Yes
HJNKYGBTSGQBDU 7.2 Ki 10 —
MLHIPHSANXGLHI 7.2 IC50 5 Yes
FMQWWPFJFLUCHZ 7.2 IC50 6 Yes
HEJQAFMDGAOYSZ 7.2 IC50 4 Yes
OEKBBQNVZPGHFU 7.2 IC50 2 —
AAVVXYJNWGIBPT 7.2 IC50 4 Yes
MNQFMKHWJNOSIX 7.2 IC50 5 Yes
MWNWUYJAANVQLN 7.2 IC50 6 Yes
VPADZEAGMFRILI 7.2 Ki 6 Yes
DODLQVHRMPIMNB 7.2 IC50 4 Yes
PTUSTBHDXAVNPJ 7.2 IC50 5 Yes
YYPITAAWUASTAE 7.2 Ki 2 —
ZFXFRRPQPVEFAM 7.2 Ki 6 Yes
AANXPIMDONQTQF 7.2 IC50 5 Yes
DONMTDNLNMLOIC 7.2 IC50 13 Yes
IHKCSGLIRGMLDE 7.2 IC50 5 Yes
KFASYAQTQCGPKV 7.2 Ki 6 Yes
UWCNFKCKFSEPKW 7.2 IC50 3 —
YNTZVOSILJPSFZ 7.2 IC50 2 —
CBLOGBROLDHLEE 7.2 IC50 6 Yes
HDOJQDDADGGFGH 7.2 IC50 6 Yes
KUDDIXBNWHQPDJ 7.2 IC50 5 Yes
XAUUSUAZNMIGRK 7.2 IC50 6 Yes
IVQNYNVXTUYYFR 7.2 IC50 4 —
OQWWHTLOLOTDPO 7.2 Ki 5 Yes
SSQXFNKOLMHXPO 7.2 Ki 6 Yes
RWOPWLLDIYQNCW 7.1 IC50 6 Yes
WUOWVIUWLFFAMY 7.1 IC50 2 —
2D structure