Target Details
| UniProt AC | P62136 |
|---|---|
| Gene Symbol | PPP1CA |
| Protein Name | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00149 (Metallophos) PF16891 (STPPase_N) |
Summary
- Multi-target molecules 2
- Clinical molecules 0
- Avg pChEMBL 6.61
KEGG Pathways (23)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Amphetamine addiction
- Cadherin signaling
- Cellular senescence
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Focal adhesion
- Herpes simplex virus 1 infection
- Hippo signaling pathway
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Long-term potentiation
- Oocyte meiosis
- Oxytocin signaling pathway
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mRNA surveillance pathway
Active Molecules (2)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
LCOSSHYAIKTVFM
|
6.6 | IC50 | 4 | — | |
DHZBEENLJMYSHQ
|
6.6 | IC50 | 2 | — |