BACE1 — MultiTargetDB

Target Details

UniProt AC	`P56817`
Gene Symbol	BACE1
Protein Name	Beta-secretase 1
Organism	Homo sapiens
Entry Name
Organism Category	Human
Pfam Domains	PF00026 (Asp)

Summary

Multi-target molecules 3,050
Clinical molecules 3
Avg pChEMBL 7.76

KEGG Pathways (1)

Alzheimer disease

Top Co-occurrence Targets

BACE2 2430 shared
CTSD 356 shared
APP 224 shared
ACHE 75 shared
CYP3A4 43 shared
IDH1 32 shared
CTSE 26 shared
CTSB 26 shared
BCHE 24 shared
KCNH2 23 shared

Active Molecules (3,050)

InChIKey	pChEMBL	Type	Targets	Clinical
`PFXZPNOPENCWPS`	8.8	IC50	2	—
`VZHFJCNPAIRJSA`	8.8	IC50	2	—
`XIOGEDRAOXMYRT`	8.8	IC50	2	—
`XQAZNKQZOGRFDR`	8.8	IC50	2	—
`BIUFVMQXBRWHLX`	8.8	IC50	2	—
`FASJIIHHSOMEFQ`	8.8	IC50	2	—
`FIUOQWQRVSRKHL`	8.8	IC50	2	—
`GKKFBOARESVMBW`	8.8	IC50	2	—
`GMQYLWZGLYEKNA`	8.8	IC50	2	—
`QTXBXLOGOUDWFQ`	8.8	IC50	2	—
`SWIQFRVYNIPNSJ`	8.8	IC50	2	—
`VDXFKYHWRXWVOF`	8.8	IC50	3	—
`XQIRFHXAOHCZDS`	8.8	IC50	2	—
`BCTKVJVJCJQKOO`	8.7	IC50	2	—
`BJPKAAAEFSVBLQ`	8.7	Ki	2	—
`BMURAXJMKMZJRB`	8.7	IC50	2	—
`CTGDPCAUHWPMSQ`	8.7	IC50	2	—
`HIQWWDCRULXYDF`	8.7	IC50	2	—
`HVXRCOUKAWTMKX`	8.7	Ki	3	—
`JBKXDUPYXMBOQP`	8.7	IC50	2	—
`PQVUIOFLWIGLEN`	8.7	Ki	3	—
`QWWBKEHWUIMNGN`	8.7	IC50	2	—
`VNTYARFSJRGDMJ`	8.7	IC50	2	—
`VOOFSJSMHWHJPL`	8.7	IC50	2	—
`YCXRAGJRMCYSLB`	8.7	IC50	2	—
`ZFNVGDSREKPUGX`	8.7	IC50	2	—
`DIDCPXSDZDVMCX`	8.7	IC50	2	—
`FKDHZVSIRLZHTD`	8.7	IC50	2	—
`ULUVFLUZTKOQFK`	8.7	IC50	2	—
`DWQBWXKENFEBOL`	8.7	IC50	2	—
`IKXTYERQAYAFRG`	8.7	Ki	2	—
`MBTYDIZXILEMMV`	8.7	IC50	2	—
`NVPONHBMBXSANB`	8.7	IC50	2	—
`OMRBGNNPYNAVLS`	8.7	IC50	2	—
`OOLWSXXSHVERMM`	8.7	IC50	2	—
`QARZSAHNYVWRSL`	8.7	IC50	2	—
`QHATUSKGDTYXBK`	8.7	IC50	2	—
`QYPZKGAQRCJRQN`	8.7	Ki	2	—
`PYWMONRKFRDZLN`	8.7	IC50	2	—
`ULQZASLUNPAZRK`	8.7	IC50	2	—
`AGNMDKJKGFYLMR`	8.7	Ki	2	—
`AMHKQZGSNKYDKI`	8.7	Ki	2	—
`ASCVRCHPGUMCIB`	8.7	IC50	2	—
`BCDWEYSMCDBNJS`	8.7	IC50	2	—
`BFQREBABDXGEMX`	8.7	Ki	2	—
`BNYKBTUCVAJFLG`	8.7	Ki	2	—
`DEPPEMUWPWWMIN`	8.7	IC50	2	—
`DFYAUWDSHXLSJC`	8.7	IC50	2	—
`DFYAUWDSHXLSJC`	8.7	IC50	2	—
`FLBGWESVICALMG`	8.7	Ki	2	—