Target Details
| UniProt AC | P54709 |
|---|---|
| Gene Symbol | ATP1B3 |
| Protein Name | Sodium/potassium-transporting ATPase subunit beta-3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00287 (Na_K-ATPase) |
Summary
- Multi-target molecules 120
- Clinical molecules 0
- Avg pChEMBL 6.93
KEGG Pathways (19)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Bile secretion
- Carbohydrate digestion and absorption
- Cardiac muscle contraction
- Cytoskeleton in muscle cells
- Endocrine and other factor-regulated calcium reabsorption
- Gastric acid secretion
- Insulin secretion
- Mineral absorption
- Pancreatic secretion
- Protein digestion and absorption
- Proximal tubule bicarbonate reclamation
- Salivary secretion
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (120)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MNSAQQBARMYNHI
|
8.5 | IC50 | 8 | — | |
GCAMATFHDAABBK
|
8.4 | Ki | 5 | — | |
ONAUXUUPVFWATH
|
8.4 | Ki | 5 | — | |
SBVAMPLOGURESG
|
8.4 | Ki | 5 | — | |
BVEFYVNGHVRRTO
|
8.2 | Ki | 5 | — | |
WQMLFJWIKARBFW
|
8.2 | IC50 | 8 | — | |
SIOAVHLOCSFVAJ
|
8.2 | Ki | 5 | — | |
MNSAQQBARMYNHI
|
8.2 | IC50 | 8 | — | |
NQOMDNMTNVQXRR
|
8.2 | IC50 | 8 | — | |
FTADYJGUJPYFPN
|
8.1 | Ki | 5 | — | |
APXSWFALEXSAHT
|
8.1 | IC50 | 8 | — | |
WTGVYUBCTJVMHT
|
8.1 | IC50 | 8 | — | |
LJUOSQZLMDHEKF
|
8.1 | Ki | 5 | — | |
UQVZKNPXASQMJQ
|
8.1 | IC50 | 8 | — | |
NJOZSUQORBIBBP
|
8.0 | Ki | 5 | — | |
ZZSCZRRDHAFLAV
|
8.0 | Ki | 5 | — | |
IJOBTPPMUDSRAS
|
8.0 | Ki | 5 | — | |
STBLRDWXSCHDBD
|
8.0 | Ki | 5 | — | |
SALCYFHXTUYGSY
|
7.9 | Ki | 5 | — | |
LJRWCHFVXQLGOI
|
7.9 | IC50 | 8 | — | |
UNYFXQCNOFHMAF
|
7.9 | Ki | 5 | — | |
LCGZRYIGXYRVKQ
|
7.8 | Ki | 5 | — | |
BHLQJIKCXBAVDX
|
7.8 | Ki | 5 | — | |
CMHWMOGWFZWDMR
|
7.8 | IC50 | 8 | — | |
JHVKYSPGICHFOW
|
7.8 | IC50 | 8 | — | |
CKPNOQUCOCLXEJ
|
7.7 | IC50 | 8 | — | |
ZEJHHDNVCMFAKT
|
7.7 | Ki | 5 | — | |
QEEBRPGZBVVINN
|
7.7 | IC50 | 10 | — | |
RXELIABRBGFTHS
|
7.6 | Ki | 5 | — | |
GUEJIEJTPBVIPA
|
7.6 | Ki | 5 | — | |
MTBSMTBFZVSBGI
|
7.6 | IC50 | 8 | — | |
WDJUZGPOPHTGOT
|
7.5 | Ki | 11 | — | |
XSFLNQNQRJJZBO
|
7.5 | IC50 | 8 | — | |
CMHWMOGWFZWDMR
|
7.5 | IC50 | 8 | — | |
LQVQTKIMPALRSS
|
7.4 | IC50 | 8 | — | |
QRGJTLPIYAQSBZ
|
7.3 | IC50 | 8 | — | |
CMHWMOGWFZWDMR
|
7.3 | IC50 | 8 | — | |
MWKSRKSEWLRPBL
|
7.3 | Kd | 1075 | — | |
SMNOMUNBNUEWQY
|
7.3 | IC50 | 8 | — | |
STVMVMIOOIYJIL
|
7.2 | IC50 | 8 | — | |
XZTUSOXSLKTKJQ
|
7.2 | IC50 | 9 | — | |
ITRLYOYEKVDKEE
|
7.2 | IC50 | 8 | — | |
RHMPRGRMPQFVCB
|
7.1 | IC50 | 8 | — | |
CFQQWIGJDYSXSJ
|
7.1 | IC50 | 8 | — | |
YFGQSHQFNJYAMR
|
7.1 | IC50 | 8 | — | |
CMHWMOGWFZWDMR
|
7.1 | IC50 | 8 | — | |
XDRNASYUVVKVMX
|
7.1 | IC50 | 8 | — | |
BWIFYTYSHZTELV
|
7.0 | Ki | 5 | — | |
DCXOCWYTNAVQBU
|
7.0 | IC50 | 8 | — | |
DUBHNQVGESAENE
|
7.0 | IC50 | 8 | — |