Target Details
| UniProt AC | P54646 |
|---|---|
| Gene Symbol | PRKAA2 |
| Protein Name | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16579 (AdenylateSensor) PF21147 (AMPK_alpha_AID) PF00069 (Pkinase) |
Summary
- Multi-target molecules 75
- Clinical molecules 17
- Avg pChEMBL 7.09
KEGG Pathways (20)
- AMPK signaling pathway
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Apelin signaling pathway
- Autophagy - animal
- Circadian rhythm
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Glucagon signaling pathway
- Hypertrophic cardiomyopathy
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Non-alcoholic fatty liver disease
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Thermogenesis
- Tight junction
- mTOR signaling pathway
Active Molecules (75)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XLFNLJYGUOLEJS
|
6.7 | IC50 | 26 | — | |
IUDLPZTURGVXEA
|
6.7 | Kd | 7 | — | |
HEPDAJRNJBNJAE
|
6.7 | IC50 | 15 | Yes | |
PIVGOZQUWKCUID
|
6.6 | IC50 | 7 | — | |
VCLMLPXAUIQEEM
|
6.6 | IC50 | 7 | — | |
OOQJIJYKWXLQNC
|
6.5 | IC50 | 16 | Yes | |
CTNPALGJUAXMMC
|
6.5 | Kd | 151 | — | |
GCIKSSRWRFVXBI
|
6.5 | Kd | 109 | Yes | |
YYLKKYCXAOBSRM
|
6.4 | Kd | 191 | — | |
BMGQWWVMWDBQGC
|
6.3 | Kd | 147 | Yes | |
BMGQWWVMWDBQGC
|
6.3 | Kd | 91 | Yes | |
ZXOKHOODFVNZIC
|
6.3 | IC50 | 7 | — | |
CQZOSLVFDRPCFJ
|
6.3 | IC50 | 7 | — | |
WNLKAYDTKKISBN
|
6.2 | IC50 | 7 | — | |
INGGFDWTZNSBPY
|
6.1 | IC50 | 7 | — | |
NHHQJBCNYHBUSI
|
6.1 | Kd | 220 | — | |
OYONTEXKYJZFHA
|
6.1 | Kd | 69 | Yes | |
NGDYCJGYGAYDIM
|
6.1 | IC50 | 7 | — | |
PIQCTGMSNWUMAF
|
6.1 | Kd | 137 | Yes | |
UKBGBACORPRCGG
|
6.1 | IC50 | 17 | — | |
ZWIGVNWZHBPXNS
|
6.1 | IC50 | 7 | — | |
BUMYTKZYNNGHLL
|
6.0 | IC50 | 7 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — |