Target Details
| UniProt AC | P54646 |
|---|---|
| Gene Symbol | PRKAA2 |
| Protein Name | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16579 (AdenylateSensor) PF21147 (AMPK_alpha_AID) PF00069 (Pkinase) |
Summary
- Multi-target molecules 75
- Clinical molecules 17
- Avg pChEMBL 7.09
KEGG Pathways (20)
- AMPK signaling pathway
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Apelin signaling pathway
- Autophagy - animal
- Circadian rhythm
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Glucagon signaling pathway
- Hypertrophic cardiomyopathy
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Non-alcoholic fatty liver disease
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Thermogenesis
- Tight junction
- mTOR signaling pathway
Active Molecules (75)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FJNHSBVZTQFKEF
|
9.0 | IC50 | 7 | — | |
JKGJLUCJLNJXKG
|
8.6 | IC50 | 7 | — | |
GUBJNPWVIUFSTR
|
8.4 | Kd | 103 | — | |
FCLPVPNWFDOVKL
|
8.4 | Ki | 11 | — | |
NOMBUNHXDWBICV
|
8.3 | Ki | 11 | — | |
CXYVYGXMFQSTKH
|
8.2 | IC50 | 7 | — | |
OZFFKOSQNBBYCA
|
8.2 | IC50 | 12 | — | |
XRDMDDSSWUSOAX
|
8.1 | IC50 | 7 | — | |
WGWCRXQUBYJTRA
|
8.0 | Ki | 11 | — | |
OFIFLUFVENTCNZ
|
8.0 | IC50 | 11 | — | |
HKSZLNNOFSGOKW
|
7.9 | Kd | 408 | — | |
HKSZLNNOFSGOKW
|
7.9 | Kd | 213 | — | |
MXHQJSWMMQETFE
|
7.8 | IC50 | 8 | — | |
WQUGCKCCOOBUNT
|
7.8 | IC50 | 7 | — | |
MHRSBLMFDBDIOU
|
7.8 | IC50 | 3 | — | |
LHDKPFSHXFFALR
|
7.7 | IC50 | 7 | — | |
HTVNZZYDHQNFBS
|
7.7 | IC50 | 3 | — | |
QZCUYXGDXFPQEA
|
7.7 | IC50 | 7 | — | |
NTZCHZCFSJZAQG
|
7.7 | IC50 | 7 | — | |
MJJALKDDGIKVBE
|
7.6 | Ki | 30 | Yes | |
PIPKBPQXMOCACO
|
7.5 | IC50 | 2 | — | |
MRMDURIHTGUZQI
|
7.5 | IC50 | 7 | — | |
MLSDVCJXCYFKAJ
|
7.4 | IC50 | 3 | — | |
NXSJMRCTGYTSTK
|
7.3 | Kd | 200 | — | |
OSVUGUHRKMMBSE
|
7.3 | Kd | 170 | — | |
HCSLNMZYDZLMOP
|
7.3 | IC50 | 3 | — | |
QQWUGDVOUVUTOY
|
7.3 | Kd | 231 | Yes | |
MBTDIENWIYANIG
|
7.3 | IC50 | 5 | Yes | |
UIARLYUEJFELEN
|
7.2 | Kd | 289 | Yes | |
IQUHNNUWFFXNMM
|
7.2 | IC50 | 2 | — | |
OFPXCBKYWWZZGT
|
7.2 | IC50 | 7 | — | |
WMXDIPVFXWNELM
|
7.2 | IC50 | 14 | Yes | |
LIZNIAKSBJKPQC
|
7.2 | IC50 | 3 | — | |
JPQIKBXALJNAKG
|
7.2 | IC50 | 3 | — | |
CBVYRMZAJKSDGJ
|
7.1 | IC50 | 2 | — | |
WNDUJGBGBDASMN
|
7.1 | IC50 | 2 | — | |
XZXHXSATPCNXJR
|
7.1 | Kd | 165 | Yes | |
ZSSGLTYUJFFIAZ
|
7.1 | IC50 | 2 | — | |
UJGXTMZILSGDLG
|
7.0 | IC50 | 5 | Yes | |
WINHZLLDWRZWRT
|
7.0 | Kd | 201 | Yes | |
GRRWNPDZXOTJNA
|
7.0 | IC50 | 2 | — | |
BZYRCHBRDGOULK
|
7.0 | IC50 | 2 | — | |
NEXGBSJERNQRSV
|
7.0 | IC50 | 3 | — | |
XHBVYDAKJHETMP
|
7.0 | IC50 | 24 | Yes | |
NICPYYDKEPDTPW
|
7.0 | IC50 | 2 | — | |
BPMMMRKHRUQAAY
|
6.9 | IC50 | 7 | — | |
JRKYKAKARRYSSS
|
6.8 | IC50 | 14 | Yes | |
MUXSMSOGTBJZDC
|
6.8 | IC50 | 2 | — | |
UDMBCSSLTHHNCD
|
6.8 | Kd | 11 | — | |
LLRSNVNZYTWKPN
|
6.7 | IC50 | 7 | — |