Target Details
| UniProt AC | P53779 |
|---|---|
| Gene Symbol | MAPK10 |
| Protein Name | Mitogen-activated protein kinase 10 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 625
- Clinical molecules 259
- Avg pChEMBL 7.25
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Associated Diseases (1)
Active Molecules (625)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NJZPPBSOOUXHEF
|
7.4 | IC50 | 3 | Yes | |
CCZSCWIBOWLLIO
|
7.4 | IC50 | 2 | Yes | |
BBAVPRQJJGDYDV
|
7.3 | IC50 | 2 | — | |
CDMGBJANTYXAIV
|
7.3 | Kd | 34 | Yes | |
QHKYPYXTTXKZST
|
7.3 | Kd | 28 | — | |
YYMDLFSNIFIZLY
|
7.3 | IC50 | 2 | — | |
CMNVQEMSBQLCIT
|
7.3 | IC50 | 2 | — | |
FAJOBNJTLWHURK
|
7.3 | IC50 | 2 | — | |
KXNZPASCSDMHFQ
|
7.3 | IC50 | 5 | Yes | |
LRUPHJAQKSRDNC
|
7.3 | IC50 | 2 | Yes | |
UCZOJYXXXUINID
|
7.3 | IC50 | 2 | — | |
ZDJZJCGVCBBGDA
|
7.3 | IC50 | 2 | Yes | |
BMZLRKZLCCIVNX
|
7.3 | IC50 | 2 | — | |
GGSIOFMZSJTMMB
|
7.3 | IC50 | 2 | — | |
GMOGCDFLNRXOJV
|
7.3 | IC50 | 3 | Yes | |
HKSZLNNOFSGOKW
|
7.3 | Ki | 118 | — | |
NGFCRLVABQTLPT
|
7.3 | IC50 | 3 | Yes | |
YYLKKYCXAOBSRM
|
7.3 | Kd | 191 | — | |
FXBNFLKLXHFULB
|
7.3 | IC50 | 3 | Yes | |
KQMPRSZTUSSXND
|
7.3 | IC50 | 4 | Yes | |
UVXXVTKNDYEVAL
|
7.3 | IC50 | 2 | — | |
XIUOLJTWTRUVGZ
|
7.3 | IC50 | 2 | — | |
AQGSJPJSRCAJNS
|
7.3 | IC50 | 2 | — | |
CUFBUESSXCZHQS
|
7.3 | IC50 | 6 | — | |
HGNBJCGHXCRROP
|
7.3 | IC50 | 2 | — | |
OHUXKIXTONEVBL
|
7.3 | IC50 | 3 | Yes | |
YTNDEFNPJUZDTP
|
7.3 | IC50 | 3 | — | |
CEUMJZPOGFBDDM
|
7.3 | IC50 | 2 | — | |
ARMFMDYRYOKSOW
|
7.2 | IC50 | 5 | Yes | |
PTVSTQCTVOIQBP
|
7.2 | IC50 | 3 | — | |
VGQNDBIBHCCFKP
|
7.2 | IC50 | 3 | — | |
GZOYOEIHAGHGFM
|
7.2 | IC50 | 6 | — | |
BILUVSXSPJVCMC
|
7.2 | IC50 | 2 | Yes | |
CUIDQTVRAWOMCM
|
7.2 | IC50 | 7 | Yes | |
FUDMBWNGRHHUHL
|
7.2 | IC50 | 2 | — | |
NJOQHORLRFTUGK
|
7.2 | IC50 | 2 | Yes | |
XQHYPIHJXWTXPZ
|
7.2 | IC50 | 3 | Yes | |
YPLNLOJZEWIBMR
|
7.2 | IC50 | 2 | — | |
BKLYUVKUMMLBIJ
|
7.2 | IC50 | 2 | — | |
IFQKWVFKEBTLIM
|
7.2 | IC50 | 2 | — | |
JUKUQWGWZSESAV
|
7.2 | Ki | 3 | Yes | |
SRJUPLSEYKRYTF
|
7.2 | IC50 | 2 | — | |
YAOWLMDOOICXCZ
|
7.2 | IC50 | 3 | Yes | |
ZRSKGCIFXQCBBO
|
7.2 | IC50 | 2 | Yes | |
LUZNKSCCMSULRH
|
7.2 | IC50 | 2 | — | |
PYFMPAWBPVAOQN
|
7.2 | IC50 | 2 | — | |
QXNPNLLIZGVUPQ
|
7.2 | IC50 | 3 | Yes | |
VMVANPCSWYULOT
|
7.2 | Kd | 3 | — | |
WBSWWONMTZEOGS
|
7.2 | Kd | 5 | — | |
DUKJABPGWUISRC
|
7.2 | IC50 | 10 | — |