Target Details
| UniProt AC | P53779 |
|---|---|
| Gene Symbol | MAPK10 |
| Protein Name | Mitogen-activated protein kinase 10 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 625
- Clinical molecules 259
- Avg pChEMBL 7.25
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Associated Diseases (1)
Active Molecules (625)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZGDGIGKBBZVIEF
|
7.6 | IC50 | 2 | — | |
CPLDEGFBMDVVMO
|
7.6 | IC50 | 2 | — | |
JVBXQJUJOCLPLK
|
7.6 | IC50 | 2 | — | |
OIENACMNANMKKJ
|
7.6 | IC50 | 2 | — | |
QZVKYTBQVHAICK
|
7.6 | IC50 | 2 | Yes | |
JCKBTQZTGPJTII
|
7.5 | IC50 | 3 | Yes | |
UVJIRZNCCXDTBQ
|
7.5 | IC50 | 2 | — | |
IOZQORJWOUBHKH
|
7.5 | IC50 | 3 | Yes | |
DFRPRNRPOSSJQZ
|
7.5 | IC50 | 2 | Yes | |
DOJMTDCTCJKZNL
|
7.5 | IC50 | 2 | — | |
HDGJMVJJOYGVSR
|
7.5 | IC50 | 3 | Yes | |
JAPSMYSZFOTZPZ
|
7.5 | IC50 | 2 | — | |
MJUMMJXVFYUVJS
|
7.5 | IC50 | 2 | — | |
WNTHBRVKPVTIQB
|
7.5 | IC50 | 3 | Yes | |
YLCVJWYVKHOSRE
|
7.5 | IC50 | 3 | Yes | |
DSBYFQXQZZQAFZ
|
7.5 | IC50 | 2 | — | |
JMOMBPSAYLGZAN
|
7.5 | IC50 | 4 | Yes | |
ORAWIJDEGBHDCO
|
7.5 | IC50 | 4 | Yes | |
SIBBXUMRESEGRS
|
7.5 | IC50 | 3 | — | |
WXTIZLXTOMJFTP
|
7.5 | IC50 | 3 | — | |
HVLBTSWQHJSANX
|
7.5 | IC50 | 3 | Yes | |
IBGLGMOPHJQDJB
|
7.5 | IC50 | 3 | Yes | |
IPPNJZWFNCNYSG
|
7.5 | IC50 | 3 | — | |
PVBFXVLGPVXIGL
|
7.5 | IC50 | 2 | Yes | |
WTYOGZPSBLDMQY
|
7.5 | IC50 | 3 | Yes | |
YTPKEJXVUUNXRA
|
7.5 | IC50 | 4 | Yes | |
ANCCTLHKRLRSAF
|
7.5 | IC50 | 2 | — | |
GLVDZCDUMFNCFY
|
7.5 | IC50 | 3 | Yes | |
HSEASLMARZYTKL
|
7.5 | IC50 | 3 | — | |
NKKDRSDFMZYYCB
|
7.5 | IC50 | 6 | — | |
QCQCMNUQTMIKHU
|
7.5 | IC50 | 2 | Yes | |
QJLJKYOXNJDYMM
|
7.5 | IC50 | 2 | — | |
IHBXLESUKAAQDQ
|
7.5 | IC50 | 3 | Yes | |
JGHISYSDWKNXIA
|
7.5 | IC50 | 3 | — | |
BDLXZJHUOJNXIO
|
7.5 | IC50 | 2 | Yes | |
FPVKFPPNOMNINZ
|
7.5 | IC50 | 2 | — | |
MSQAJMDTOWUMOF
|
7.5 | IC50 | 2 | — | |
YKQKOWXCFYHZEG
|
7.5 | IC50 | 2 | — | |
RDSACQWTXKSHJT
|
7.4 | Kd | 5 | — | |
SRTMONQYBOXBGE
|
7.4 | IC50 | 3 | Yes | |
FTIAKTLRFKSDFR
|
7.4 | IC50 | 10 | Yes | |
NHHQJBCNYHBUSI
|
7.4 | Kd | 220 | — | |
SHQNUFDSTNIIBP
|
7.4 | IC50 | 2 | Yes | |
VGQNDBIBHCCFKP
|
7.4 | IC50 | 3 | — | |
OWVJFLOWTRTEOY
|
7.4 | IC50 | 2 | — | |
QAPNZNFLFCTLFN
|
7.4 | IC50 | 2 | — | |
GIIITGYQMLZQJE
|
7.4 | IC50 | 2 | — | |
JNEVMXDLGBKOSK
|
7.4 | IC50 | 2 | — | |
NDZXQUQZWJOGKU
|
7.4 | IC50 | 2 | — | |
PSUZEBSSYLZYCL
|
7.4 | IC50 | 2 | Yes |