Target Details
| UniProt AC | P53779 |
|---|---|
| Gene Symbol | MAPK10 |
| Protein Name | Mitogen-activated protein kinase 10 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 625
- Clinical molecules 259
- Avg pChEMBL 7.25
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Associated Diseases (1)
Active Molecules (625)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YJIHRITUIVWNPX
|
7.8 | IC50 | 4 | Yes | |
ACGBFWCBVIXTPZ
|
7.8 | IC50 | 3 | Yes | |
FJVVBMGXZMJPOI
|
7.8 | IC50 | 3 | — | |
FJVVBMGXZMJPOI
|
7.8 | IC50 | 3 | — | |
GKAVCPBETIUUNC
|
7.8 | IC50 | 2 | Yes | |
GLWXMYOBTQMICW
|
7.8 | IC50 | 3 | Yes | |
IUGSVSMCSCKMLY
|
7.8 | IC50 | 3 | Yes | |
LVURNSYDLIRBTC
|
7.8 | IC50 | 2 | — | |
DVEYHFXOGUYFBU
|
7.8 | Kd | 5 | — | |
JCJAEEODSKNKTC
|
7.8 | IC50 | 6 | Yes | |
MLIRIWBFADTRLZ
|
7.8 | IC50 | 4 | Yes | |
SCIILXOOXBQBFM
|
7.8 | Ki | 3 | Yes | |
SNAKELXBWICEIB
|
7.8 | IC50 | 2 | — | |
YZJYYYWPZRYBLV
|
7.8 | IC50 | 3 | Yes | |
ARVSBTXGNYKBJK
|
7.8 | IC50 | 2 | — | |
LRVSISWQSCNQKL
|
7.8 | IC50 | 3 | Yes | |
QLEWHSZIKRAOAP
|
7.8 | IC50 | 2 | — | |
CSDDCHPGQGWRLI
|
7.8 | Ki | 5 | Yes | |
BUCXDWXDBZUFMV
|
7.7 | IC50 | 3 | Yes | |
PPJNVHSJLHVKBI
|
7.7 | IC50 | 2 | — | |
RMQLRJIXYUSAHW
|
7.7 | IC50 | 2 | Yes | |
JYYLVUFNAHSSFE
|
7.7 | Kd | 9 | — | |
VFFOCQZCDTURBY
|
7.7 | IC50 | 3 | Yes | |
BMPQHQFIJBXIOA
|
7.7 | IC50 | 3 | Yes | |
IKVLVCWXKRSDND
|
7.7 | IC50 | 2 | Yes | |
MMCVYWQYORICCQ
|
7.7 | IC50 | 3 | Yes | |
SVIZILSXAQTEQC
|
7.7 | IC50 | 2 | — | |
TYFREKXWJOQZSG
|
7.7 | IC50 | 2 | — | |
ULAZKRKKWCLPNC
|
7.7 | IC50 | 3 | — | |
UMVDHPFXGXTJAT
|
7.7 | IC50 | 2 | — | |
BPAKBBJBLXVUPC
|
7.7 | IC50 | 2 | — | |
SCDOWHQVNDXVPB
|
7.7 | IC50 | 3 | Yes | |
DXTYYUXUIQZDHR
|
7.7 | IC50 | 3 | Yes | |
ILUOKEKSMZBBQY
|
7.6 | IC50 | 3 | — | |
PANZFUIIZSOBRK
|
7.6 | IC50 | 2 | — | |
UKLFJWKRYNOIGW
|
7.6 | IC50 | 2 | — | |
IJTANTDZFOCBKK
|
7.6 | IC50 | 3 | Yes | |
LIWQYJBFPZCBRH
|
7.6 | IC50 | 2 | — | |
NZNGPQXBCNZDCZ
|
7.6 | IC50 | 4 | Yes | |
OOXCRLOLUWLQCN
|
7.6 | IC50 | 3 | Yes | |
QBROFJFJPQJMEQ
|
7.6 | IC50 | 3 | — | |
QKJMPSJTHLLZPU
|
7.6 | IC50 | 3 | Yes | |
SLHHRPHWICLQNW
|
7.6 | IC50 | 2 | — | |
TUFAYPAXFHVGTH
|
7.6 | IC50 | 3 | — | |
YFPHGGTUESKWNB
|
7.6 | IC50 | 2 | — | |
HJUDFJRTVGXBRF
|
7.6 | IC50 | 3 | Yes | |
OWRXHGAFWZFFCW
|
7.6 | Ki | 113 | — | |
RQEFLPVRZJPIAZ
|
7.6 | IC50 | 2 | — | |
UNUTTXCETMYXRD
|
7.6 | IC50 | 3 | Yes | |
UYSFVRNMYWGKIE
|
7.6 | IC50 | 2 | — |