Target Details
| UniProt AC | P53779 |
|---|---|
| Gene Symbol | MAPK10 |
| Protein Name | Mitogen-activated protein kinase 10 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 625
- Clinical molecules 259
- Avg pChEMBL 7.25
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Associated Diseases (1)
Active Molecules (625)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AMLKAXKHAOGCFY
|
8.5 | IC50 | 2 | — | |
CHWHUQGYVMHMGN
|
8.5 | IC50 | 2 | — | |
DGTWHZKHMUDXOY
|
8.5 | IC50 | 3 | Yes | |
HYNNWLVWJXWXFO
|
8.5 | IC50 | 2 | — | |
JXIRXFNFPFUNQQ
|
8.5 | IC50 | 2 | — | |
KKKRKRMVJRHDMG
|
8.5 | Kd | 14 | — | |
LGICVDGDWJJCIH
|
8.5 | IC50 | 2 | — | |
NIQVLUYKQSAUSE
|
8.5 | IC50 | 2 | — | |
QHYSKDAWIUFROA
|
8.5 | IC50 | 3 | Yes | |
RDFFZPKZBXFQEF
|
8.5 | IC50 | 3 | Yes | |
XTFFMIPOKWLBRH
|
8.5 | IC50 | 3 | — | |
OWHSAASMRWOHHO
|
8.5 | IC50 | 3 | Yes | |
WMTFXHFSJAESMU
|
8.5 | IC50 | 3 | Yes | |
CNOBUOFKVJJORP
|
8.4 | IC50 | 3 | — | |
JLOWBCPGKBVSGH
|
8.4 | IC50 | 3 | — | |
MDCMULVKRBERMG
|
8.4 | IC50 | 2 | Yes | |
SMBXDJJTCBKNRG
|
8.4 | IC50 | 2 | — | |
XNLNCNYXYAAOEA
|
8.4 | IC50 | 2 | — | |
FKBQOEJUXLTCGJ
|
8.4 | IC50 | 3 | — | |
DSFZMDKHAONJTA
|
8.3 | IC50 | 2 | — | |
GLWXMYOBTQMICW
|
8.3 | IC50 | 3 | Yes | |
KDMADGZAPDHVHE
|
8.3 | IC50 | 6 | — | |
MIFPZJRPCSILQA
|
8.3 | IC50 | 3 | — | |
SZNPQONVZOSPLO
|
8.3 | Ki | 3 | Yes | |
TXUPRVNNKMSBLZ
|
8.3 | IC50 | 3 | Yes | |
VYNVVWLFRMWZRV
|
8.3 | IC50 | 3 | — | |
XMMMCYBZGARUKP
|
8.3 | IC50 | 4 | — | |
XXPJQSSWRLLVEZ
|
8.3 | IC50 | 3 | — | |
ZOUZXNPDTXVSEH
|
8.3 | IC50 | 3 | Yes | |
ZYWJPJYYTUCZHN
|
8.3 | IC50 | 3 | Yes | |
KVDDBBDCWPLOFR
|
8.3 | IC50 | 3 | — | |
LGTYWJCIEQTIIP
|
8.3 | IC50 | 3 | Yes | |
NPDBZGWDNRJYIQ
|
8.3 | IC50 | 2 | — | |
AEIKXFACENTHCD
|
8.2 | IC50 | 3 | Yes | |
AJMFKZZQEDNOJZ
|
8.2 | IC50 | 4 | — | |
BZKOXELLQJFKSQ
|
8.2 | IC50 | 3 | Yes | |
IBGLGMOPHJQDJB
|
8.2 | IC50 | 5 | — | |
RWOFIHYHMILOTJ
|
8.2 | IC50 | 3 | Yes | |
WNRCGOJLZOLSJN
|
8.2 | IC50 | 3 | Yes | |
YSSREBGNECUESU
|
8.2 | IC50 | 3 | Yes | |
ZZGXJNUHZVCAOW
|
8.2 | IC50 | 3 | Yes | |
UYJNQQDJUOUFQJ
|
8.2 | IC50 | 68 | — | |
ZBEPMOZEXLGCTF
|
8.2 | IC50 | 3 | — | |
RQVKVJIRFKVPBF
|
8.2 | Ki | 13 | — | |
DEPFXQSAHGKYPV
|
8.2 | IC50 | 2 | Yes | |
GISZVPBPRUQLCY
|
8.2 | IC50 | 2 | — | |
MTFAYLZZDJGFGV
|
8.2 | IC50 | 2 | — | |
RQUGSKZRACGFFU
|
8.2 | IC50 | 2 | Yes | |
UJLHONOXXNLUDV
|
8.2 | IC50 | 3 | Yes | |
VINQLWACVZJJIO
|
8.2 | IC50 | 3 | Yes |