Target Details
| UniProt AC | P53779 |
|---|---|
| Gene Symbol | MAPK10 |
| Protein Name | Mitogen-activated protein kinase 10 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 625
- Clinical molecules 259
- Avg pChEMBL 7.25
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Associated Diseases (1)
Active Molecules (625)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MGGUVSLBKUKUGR
|
6.2 | IC50 | 3 | Yes | |
NIHQLDJHBMNLCZ
|
6.2 | IC50 | 3 | — | |
OHNNRNYUHNGDNO
|
6.2 | IC50 | 15 | — | |
BXZQZGKOTDCAKN
|
6.2 | IC50 | 3 | — | |
OHMPXDCOVKOOAN
|
6.2 | IC50 | 4 | — | |
WUFVFWHZRSJNAV
|
6.2 | IC50 | 4 | Yes | |
IMELNYJZDCCKFI
|
6.2 | IC50 | 2 | — | |
PLJKGPIWOOUPAJ
|
6.2 | IC50 | 3 | — | |
UBQAXNUSTYBVJI
|
6.2 | IC50 | 3 | Yes | |
NERJSNYOGGKVRR
|
6.2 | IC50 | 3 | — | |
GUFXTCNPJGZWOZ
|
6.2 | IC50 | 3 | Yes | |
JDCPDRSOEKCKGX
|
6.2 | IC50 | 2 | Yes | |
MWQGXLPPKAMINM
|
6.2 | IC50 | 2 | Yes | |
VMQZTUVADKYPAR
|
6.2 | IC50 | 2 | Yes | |
VTTJSUDCCDBRRF
|
6.2 | IC50 | 3 | Yes | |
HDAJDNHIBCDLQF
|
6.2 | IC50 | 14 | — | |
PBBRWFOVCUAONR
|
6.2 | Ki | 26 | Yes | |
PIQCTGMSNWUMAF
|
6.2 | Ki | 137 | Yes | |
BKDFUBKUTUBYSW
|
6.2 | IC50 | 3 | — | |
LARBATGPSUALDD
|
6.2 | IC50 | 5 | — | |
OYPFBHGNPRGZHS
|
6.2 | IC50 | 3 | Yes | |
CWJLAVRXVFHDSJ
|
6.2 | IC50 | 13 | — | |
LYMPHEWUZFSXGM
|
6.2 | IC50 | 2 | Yes | |
ZJRIWXARVRPGQC
|
6.2 | IC50 | 2 | — | |
GCFIASDOZHNRKP
|
6.2 | IC50 | 3 | — | |
GKDIRDHQIHCEGG
|
6.2 | IC50 | 3 | — | |
RJDMNHJOMJVPHJ
|
6.2 | IC50 | 2 | Yes | |
WHORUVUQHFFPNW
|
6.2 | IC50 | 2 | Yes | |
XRHSVYXJHZMCCY
|
6.2 | IC50 | 3 | Yes | |
ZFGJERKBORCEBU
|
6.2 | IC50 | 2 | Yes | |
MPAZWRVTQIDWSL
|
6.2 | IC50 | 3 | — | |
MZOBZDVFDCQUAV
|
6.2 | IC50 | 2 | — | |
VZEONOGFXYTZGT
|
6.2 | IC50 | 2 | — | |
WWHNHBJMWMVKHQ
|
6.2 | IC50 | 4 | Yes | |
DDHASJXGNUWZTM
|
6.1 | Ki | 2 | — | |
DDHASJXGNUWZTM
|
6.1 | Ki | 2 | — | |
ODPGGGTTYSGTGO
|
6.1 | Kd | 153 | — | |
FYSRKRZDBHOFAY
|
6.1 | Kd | 8 | — | |
JNPMSEMUYZIVNF
|
6.1 | Ki | 2 | — | |
KFIDJSXUJCJHQB
|
6.1 | IC50 | 6 | — | |
KSZHRLGDJPCAID
|
6.1 | IC50 | 2 | Yes | |
MNEXDVSJIUQQRH
|
6.1 | IC50 | 6 | — | |
XGALLCVXEZPNRQ
|
6.1 | Ki | 39 | Yes | |
CCEORUFGHAKXQE
|
6.1 | IC50 | 2 | Yes | |
JIYYYSRFLXRKAB
|
6.1 | IC50 | 3 | Yes | |
NGOYZSBSNHRWEM
|
6.1 | IC50 | 3 | — | |
SRZUMCBVXNGXNY
|
6.1 | IC50 | 3 | — | |
VHPPODIXJOXBEV
|
6.1 | IC50 | 2 | Yes | |
GHLDPDGLXQCUNO
|
6.1 | IC50 | 3 | — | |
KGJRXQASMIVWCI
|
6.1 | Ki | 2 | — |