Target Details
| UniProt AC | P53779 |
|---|---|
| Gene Symbol | MAPK10 |
| Protein Name | Mitogen-activated protein kinase 10 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 625
- Clinical molecules 259
- Avg pChEMBL 7.25
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Associated Diseases (1)
Active Molecules (625)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RTMJIFPHPQZXEZ
|
6.5 | IC50 | 2 | Yes | |
GTRPPGMPULGRCP
|
6.5 | IC50 | 3 | — | |
LOLPPWBBNUVNQZ
|
6.5 | Kd | 97 | Yes | |
IPXACKINLSGATE
|
6.4 | IC50 | 2 | Yes | |
KXYHQCXHGCREEU
|
6.4 | IC50 | 2 | Yes | |
QIQWHUHEIKULHZ
|
6.4 | IC50 | 2 | Yes | |
RHFIAUKMKYHHFA
|
6.4 | IC50 | 9 | — | |
DKNUPRMJNUQNHR
|
6.4 | Kd | 33 | — | |
FHGSYAFPJQQASV
|
6.4 | IC50 | 2 | Yes | |
UZWDCWONPYILKI
|
6.4 | IC50 | 47 | — | |
XURAVYGNAAUXQP
|
6.4 | Kd | 3 | — | |
YMHGDVJMGNXBIG
|
6.4 | IC50 | 2 | Yes | |
BTRREXVQOUTSPK
|
6.4 | IC50 | 2 | — | |
WZLNUODSHWYWOC
|
6.4 | IC50 | 2 | — | |
SHBXAJXKKQHYFU
|
6.4 | IC50 | 2 | Yes | |
UGKKDOKVLSCRFL
|
6.4 | IC50 | 3 | Yes | |
UGZLJUFPCPHHSW
|
6.4 | IC50 | 3 | Yes | |
FVPQKFPGPOAQPF
|
6.4 | IC50 | 3 | — | |
KGMVZSJAPXYTKH
|
6.4 | IC50 | 23 | — | |
XVLIRDXMQGPGCW
|
6.4 | IC50 | 4 | Yes | |
CUTRCHHQYWQMFT
|
6.4 | IC50 | 2 | Yes | |
FOAAMZPWLWPKOE
|
6.4 | IC50 | 3 | — | |
CSSUHQZFWVQCSA
|
6.4 | IC50 | 2 | — | |
INUQHONAOUHTRF
|
6.4 | IC50 | 4 | — | |
PXJCEFGMIBFUGI
|
6.3 | IC50 | 3 | — | |
ALHGQWSWTWVNNB
|
6.3 | IC50 | 2 | Yes | |
HHCBMISMPSAZBF
|
6.3 | IC50 | 23 | — | |
LXZLCVFQXWMBJR
|
6.3 | IC50 | 3 | Yes | |
XVIMTHVVBGUFCB
|
6.3 | IC50 | 3 | Yes | |
BTRNKAGATHKDRE
|
6.3 | IC50 | 3 | Yes | |
CTQXMPOHMBPPMC
|
6.3 | IC50 | 3 | Yes | |
DIUBLEYZTHWMDJ
|
6.3 | IC50 | 2 | Yes | |
JZTOUVBEZONDKA
|
6.3 | Ki | 80 | — | |
SFDUUFDVJHFBRB
|
6.3 | IC50 | 4 | — | |
ZJWZDMQTDMVQQB
|
6.3 | IC50 | 3 | — | |
BHMYLUVZDOIZTR
|
6.3 | IC50 | 2 | Yes | |
DXAJWOOLPAIVJG
|
6.3 | Ki | 3 | Yes | |
FXVBEGJQINEFDZ
|
6.3 | IC50 | 2 | Yes | |
OYICHVOOWWQYDE
|
6.3 | IC50 | 2 | — | |
UPVVKGJGCKBECE
|
6.3 | IC50 | 2 | — | |
AELOZOVEWBJDJP
|
6.3 | IC50 | 2 | Yes | |
BOCQIRYQTWRJMD
|
6.3 | IC50 | 3 | — | |
MXNISZSSQGUZMA
|
6.3 | IC50 | 2 | — | |
OYXVJMGNNKEOSX
|
6.3 | IC50 | 3 | — | |
YGGYBJSDWZSAAU
|
6.3 | IC50 | 5 | — | |
APPUPKYUHWUPCJ
|
6.3 | IC50 | 3 | — | |
JIZAXYFIPHHWDF
|
6.3 | IC50 | 2 | Yes | |
PDJZASCRQRBYQS
|
6.3 | Ki | 2 | — | |
KUPWEENZVLBVNM
|
6.2 | IC50 | 3 | Yes | |
LHNIIDJUOCFXAP
|
6.2 | Kd | 20 | Yes |