Target Details
| UniProt AC | P53778 |
|---|---|
| Gene Symbol | MAPK12 |
| Protein Name | Mitogen-activated protein kinase 12 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 606
- Clinical molecules 10
- Avg pChEMBL 7.17
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (606)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VFCRJQKABYQLDB
|
7.0 | IC50 | 3 | — | |
XSINXQGWUBFCGP
|
7.0 | IC50 | 3 | — | |
KLRATASOGXHMKV
|
7.0 | IC50 | 6 | — | |
YWAGLURBYTXRAR
|
7.0 | IC50 | 4 | — | |
DAGIKZZLKORVEA
|
7.0 | IC50 | 4 | — | |
MQFHPDFEZJZDIR
|
7.0 | IC50 | 4 | — | |
NBCXZLPCCIVOKY
|
7.0 | IC50 | 5 | — | |
ODEPPRALJZKMID
|
6.9 | IC50 | 3 | — | |
ANWALZPQHPAZFO
|
6.9 | IC50 | 4 | — | |
CWIGGHRHBFIADD
|
6.9 | IC50 | 3 | — | |
JLPYLKUBAMBYDJ
|
6.9 | IC50 | 4 | — | |
KCRPPQYLFPCZML
|
6.9 | IC50 | 4 | — | |
QMCGWRVMZPNHKW
|
6.9 | IC50 | 5 | — | |
ZPXPEKQMLOAPLT
|
6.9 | IC50 | 15 | — | |
ZXAWHDKYRBFPMS
|
6.9 | IC50 | 4 | — | |
DSFLBGZXRVTGEA
|
6.9 | IC50 | 6 | — | |
QAKIGHBHPHZCJC
|
6.9 | IC50 | 4 | — | |
QXNJKUFPXJJKNH
|
6.9 | IC50 | 4 | — | |
RTDCVLCTBQDLBW
|
6.9 | IC50 | 4 | — | |
AOXUXJXIJKCXEP
|
6.9 | IC50 | 4 | — | |
AZBHFSLUTGHEPH
|
6.9 | IC50 | 6 | — | |
FNXYEOKFNVUCPL
|
6.9 | IC50 | 4 | — | |
HTFVITLDAZUSJX
|
6.9 | IC50 | 4 | — | |
KFULDVUYUMOVAX
|
6.9 | IC50 | 5 | — | |
KZLCRRAGBNSUBK
|
6.9 | IC50 | 5 | — | |
PGSYDZKLIPHTQE
|
6.9 | Kd | 4 | — | |
RGSUWKJYBMJESY
|
6.9 | IC50 | 4 | — | |
SPVCHCDBUMRZBA
|
6.9 | IC50 | 5 | — | |
UGGLIKVGGHFAIU
|
6.9 | IC50 | 4 | — | |
KMUBMDDTMBDGJK
|
6.9 | IC50 | 4 | — | |
WEACIVJSLZZZLC
|
6.9 | IC50 | 3 | — | |
CDMGBJANTYXAIV
|
6.9 | IC50 | 34 | Yes | |
BWYOYQVVRUBVGY
|
6.9 | IC50 | 4 | — | |
BJJRLHLFUBMTBH
|
6.8 | IC50 | 3 | — | |
KPDQHNUZQHJLSJ
|
6.8 | IC50 | 6 | — | |
LYMRGNVCFWWSAT
|
6.8 | IC50 | 5 | — | |
VRSHGZMFXJHCDY
|
6.8 | IC50 | 5 | — | |
MPFNOCFGLHYSEQ
|
6.8 | IC50 | 2 | — | |
SBGKNONFYWLESF
|
6.8 | IC50 | 3 | — | |
HFQBEBGFOOARGT
|
6.8 | IC50 | 4 | — | |
IXWAAWQRRFJLQU
|
6.8 | IC50 | 3 | — | |
AIZGSJRXZMRUPZ
|
6.8 | IC50 | 4 | — | |
BPLTVYXMXOYIBK
|
6.8 | IC50 | 9 | — | |
COXXCKLSWHHFDS
|
6.8 | IC50 | 5 | — | |
GCDPHNDMHYQIDA
|
6.8 | IC50 | 4 | — | |
QUZUYBVTTGUAGJ
|
6.8 | IC50 | 5 | — | |
SLEDJBMFRMKJLH
|
6.8 | IC50 | 5 | — | |
WWSVFJIFHQKQLY
|
6.8 | IC50 | 3 | — | |
FUMCKNCUEAQHCV
|
6.8 | Ki | 103 | — | |
LYNBNVBMAGDJRW
|
6.8 | Ki | 81 | — |