Target Details
| UniProt AC | P53778 |
|---|---|
| Gene Symbol | MAPK12 |
| Protein Name | Mitogen-activated protein kinase 12 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 606
- Clinical molecules 10
- Avg pChEMBL 7.17
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (606)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SXRLSMDAMBCWBT
|
7.4 | IC50 | 4 | — | |
WDFITUYPGUVBFT
|
7.4 | IC50 | 4 | — | |
ZOXBZBPUCXTGNN
|
7.4 | IC50 | 4 | — | |
KIPZYDCBLYBUMY
|
7.4 | IC50 | 4 | — | |
UCPUHUQCXKZUNH
|
7.4 | IC50 | 4 | — | |
BVWOUNUDMYJKNG
|
7.4 | IC50 | 4 | — | |
HKSZLNNOFSGOKW
|
7.4 | Kd | 213 | — | |
DBXJNQABFNNKPN
|
7.4 | Kd | 7 | — | |
PJJMRKFIVMZIOW
|
7.4 | IC50 | 4 | — | |
XJBQSGXAJXTXAC
|
7.4 | IC50 | 5 | — | |
LJSMVJCZENREBC
|
7.4 | IC50 | 4 | — | |
MIAZWLXBNITBFW
|
7.4 | IC50 | 4 | — | |
ZQUSFAUAYSEREK
|
7.4 | IC50 | 4 | — | |
GPXMVHRMRPADJD
|
7.3 | IC50 | 4 | — | |
GRFBNEAPKLWFPA
|
7.3 | IC50 | 4 | — | |
OUVNUGZFBADGIN
|
7.3 | IC50 | 4 | — | |
YEXAEGWRSZOFGW
|
7.3 | IC50 | 4 | — | |
ROKOFZNQCIIJMI
|
7.3 | IC50 | 4 | — | |
BAEFMUUEJBUVJL
|
7.3 | IC50 | 5 | — | |
PDQILYUWWBSUJV
|
7.3 | IC50 | 4 | — | |
SLHFXBSSLHCOHI
|
7.3 | Kd | 4 | — | |
JHSPKBWIYMIFKX
|
7.3 | IC50 | 5 | — | |
VPVLUCZRDCBSCN
|
7.3 | IC50 | 6 | — | |
APKKXGAJMPHCEP
|
7.3 | IC50 | 5 | — | |
BKQFXMIFPQJYMZ
|
7.3 | IC50 | 4 | — | |
FBVOZYJUBHKVRX
|
7.3 | IC50 | 2 | — | |
IBHXVVYFEIGWLJ
|
7.3 | IC50 | 4 | — | |
VDGCALOJSXKVNQ
|
7.3 | IC50 | 4 | — | |
VMANCBCSTYKPPA
|
7.3 | IC50 | 4 | — | |
ZZZJRULMCGMYRH
|
7.3 | IC50 | 4 | — | |
SHARQAUXHRDLBF
|
7.3 | IC50 | 4 | — | |
ZPKIWFITUKOGJS
|
7.3 | IC50 | 3 | — | |
VPTQOJQQTLPBGP
|
7.3 | IC50 | 4 | — | |
BOWHHQDNSQZWEF
|
7.3 | IC50 | 4 | — | |
GIBQUDGWUOVOMR
|
7.3 | IC50 | 4 | — | |
ITENSOATZCMKDD
|
7.3 | IC50 | 3 | — | |
SIOLNXSDRQRYLQ
|
7.2 | IC50 | 4 | — | |
GOUYNVPPUCUZSS
|
7.2 | IC50 | 6 | — | |
ZCDMUCUWIVFZMM
|
7.2 | IC50 | 4 | — | |
WDMJITFYAJRAJW
|
7.2 | IC50 | 4 | — | |
YEQUJOKCSZTBFS
|
7.2 | IC50 | 4 | — | |
ZGXVMEYUYQMAQX
|
7.2 | IC50 | 4 | — | |
AKMUGCMCOYELTD
|
7.2 | IC50 | 4 | — | |
HHCBMISMPSAZBF
|
7.2 | IC50 | 23 | — | |
ZBZUZJQNKUWJSS
|
7.2 | IC50 | 4 | — | |
IADKHNLYTDEPGD
|
7.2 | IC50 | 6 | — | |
UEFUTYVFNURZNH
|
7.2 | IC50 | 3 | — | |
IIOPMAYJMMUZLO
|
7.2 | IC50 | 2 | — | |
UYFZFNBZWUNCQS
|
7.2 | IC50 | 4 | — | |
AIAMQBKMZVAHHF
|
7.2 | IC50 | 4 | — |