Target Details
| UniProt AC | P53778 |
|---|---|
| Gene Symbol | MAPK12 |
| Protein Name | Mitogen-activated protein kinase 12 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 606
- Clinical molecules 10
- Avg pChEMBL 7.17
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (606)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JIFZZVZROIFPKB
|
7.6 | IC50 | 5 | — | |
SXEJPJAKKSSHHC
|
7.6 | IC50 | 4 | — | |
VOUFJXLXOWMZOG
|
7.6 | IC50 | 4 | — | |
DHNYNLNKNQJSHF
|
7.6 | Kd | 4 | — | |
HXMGCTFLLWPVFM
|
7.6 | IC50 | 6 | — | |
LNEAMQIVEZCBGU
|
7.6 | IC50 | 2 | — | |
MFPLYINPSNJRRI
|
7.6 | IC50 | 3 | — | |
VEPKQEUBKLEPRA
|
7.6 | IC50 | 11 | — | |
XPWLTGRNORHARK
|
7.6 | IC50 | 4 | — | |
TWWUNSJOKCOGKZ
|
7.6 | IC50 | 4 | — | |
FEGPYUXSDDPKOY
|
7.6 | IC50 | 5 | — | |
WLSRUNCRTNITTJ
|
7.6 | IC50 | 4 | — | |
VAUWNNIXFMIEBF
|
7.5 | IC50 | 3 | — | |
WYGVFMIQQCLMNX
|
7.5 | IC50 | 4 | — | |
YKUDVEVHRUJXLV
|
7.5 | IC50 | 5 | — | |
FJCORFQIRVXPCY
|
7.5 | IC50 | 4 | — | |
GZPYMRRCHNCWPW
|
7.5 | IC50 | 4 | — | |
ODPGGGTTYSGTGO
|
7.5 | Kd | 153 | — | |
GWAMNECAZIXYSS
|
7.5 | IC50 | 4 | — | |
GYQLVKWGHKBDMP
|
7.5 | IC50 | 6 | — | |
GZXBBHIMZJVMAU
|
7.5 | IC50 | 3 | — | |
MVCOAUNKQVWQHZ
|
7.5 | IC50 | 54 | Yes | |
SBYHQPVTFYWZBH
|
7.5 | IC50 | 4 | — | |
UOGQEKVLZDBJDM
|
7.5 | IC50 | 4 | — | |
XIPLZPXJTFHKRP
|
7.5 | IC50 | 4 | — | |
ZQJQDDLGWSLWNG
|
7.5 | IC50 | 4 | — | |
HOTOPLMUHTWMOS
|
7.5 | Kd | 4 | — | |
DKXHSOUZPMHNIZ
|
7.5 | Ki | 51 | Yes | |
SGVBVAOVXTWIJT
|
7.5 | IC50 | 3 | — | |
YMIJUBCSOKSFRU
|
7.5 | Ki | 87 | — | |
NKIIJQFBQXIXNY
|
7.5 | IC50 | 4 | — | |
VSPFURGQAYMVAN
|
7.5 | IC50 | 17 | — | |
FEFIXEMJIYHFAZ
|
7.5 | IC50 | 4 | — | |
QIBLVZMAUUVSMB
|
7.5 | IC50 | 4 | — | |
SFXQPCGNFSUNGU
|
7.5 | IC50 | 4 | — | |
CZEBZOHAXRSHBJ
|
7.4 | IC50 | 4 | — | |
NAKJVILZJGYGJO
|
7.4 | IC50 | 4 | — | |
CDJIPRNIKJOICB
|
7.4 | IC50 | 4 | — | |
LSXDMSPDXVTUDM
|
7.4 | IC50 | 4 | — | |
WFRORTCUDVWXHF
|
7.4 | IC50 | 4 | — | |
YLSFSAKXSQLGSF
|
7.4 | IC50 | 6 | — | |
FPSYUXXLCHMFRU
|
7.4 | IC50 | 4 | — | |
MSGGRRJXKDUMOF
|
7.4 | IC50 | 4 | — | |
WUDBUIUHVNECTM
|
7.4 | IC50 | 7 | — | |
CUFBUESSXCZHQS
|
7.4 | IC50 | 6 | — | |
GCBJDOWIQHMCMR
|
7.4 | Ki | 84 | — | |
IXHWMGAFLNPNII
|
7.4 | IC50 | 6 | — | |
MVJMMLFMPWITEJ
|
7.4 | Ki | 110 | — | |
NIMHPYRVDHKYEO
|
7.4 | IC50 | 4 | — | |
QUKMNFBZSMFVFB
|
7.4 | IC50 | 5 | — |