Target Details
| UniProt AC | P53778 |
|---|---|
| Gene Symbol | MAPK12 |
| Protein Name | Mitogen-activated protein kinase 12 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 606
- Clinical molecules 10
- Avg pChEMBL 7.17
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (606)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZHYRMYNGJZLEKN
|
8.0 | IC50 | 4 | — | |
BMNBPNRAKNFVAB
|
8.0 | IC50 | 4 | — | |
JUCVIQPUESHERW
|
8.0 | IC50 | 4 | — | |
SDWCOPUSJBCAAX
|
8.0 | IC50 | 4 | — | |
UTWWHRXSGYXKES
|
8.0 | IC50 | 3 | — | |
YYLIDCHASSSNQK
|
8.0 | IC50 | 4 | — | |
DTBVFMOSIXAFFR
|
8.0 | IC50 | 2 | — | |
GOMLJGVTZFYKJG
|
8.0 | IC50 | 3 | — | |
DREMCOHKCICYCA
|
7.9 | Kd | 4 | — | |
FCJMQXODPHVAOG
|
7.9 | IC50 | 4 | — | |
MSXZXFPYTVQJIL
|
7.9 | IC50 | 4 | — | |
UURQEFJLVUODIL
|
7.9 | IC50 | 4 | — | |
RNOZPQYHYKQEEX
|
7.9 | IC50 | 4 | — | |
HPLMNCNOXZFBBD
|
7.9 | Kd | 4 | — | |
JPYOIFOGVHGGQA
|
7.9 | IC50 | 4 | — | |
MKEMSFNHLLMWNR
|
7.9 | IC50 | 2 | — | |
DROUGNYFAQIMFE
|
7.9 | IC50 | 4 | — | |
GZGYXKHNMJBZKD
|
7.8 | Kd | 4 | — | |
IVBPBKLZQGEAEA
|
7.8 | Kd | 4 | — | |
OPBZEBLTFIONGE
|
7.8 | Ki | 4 | — | |
RWTFBQBPISMKTK
|
7.8 | IC50 | 4 | — | |
AGDOBCPIYPQSIB
|
7.8 | IC50 | 4 | — | |
JOUFMDMLXUIBIV
|
7.8 | IC50 | 4 | — | |
RJHSFROTHLVFBY
|
7.8 | Ki | 4 | — | |
SMDNOKALZQOTCU
|
7.8 | IC50 | 4 | — | |
BQXDLQUNDYMBSC
|
7.8 | Ki | 4 | — | |
FNZGHWSBOGBXEO
|
7.8 | IC50 | 3 | — | |
MZRCCMMKNFJJEA
|
7.8 | IC50 | 4 | — | |
QLURYKVIFSRCNJ
|
7.8 | IC50 | 4 | — | |
ROYXMGVXIACORO
|
7.8 | IC50 | 4 | — | |
HDCLCHNAEZNGNV
|
7.8 | IC50 | 4 | — | |
RNPHICWBCUQEML
|
7.8 | IC50 | 4 | — | |
RRQTXZNIXFFWAR
|
7.8 | IC50 | 4 | — | |
SNHWMEWYAPKRQL
|
7.8 | IC50 | 4 | — | |
IFLRTIBATNZOEH
|
7.7 | IC50 | 4 | — | |
JVJCVRPAUUWRBH
|
7.7 | Kd | 4 | — | |
KCXCFBQZWGUDQC
|
7.7 | IC50 | 4 | — | |
LUZARSGELRSGPD
|
7.7 | IC50 | 4 | — | |
MWUPDRLQBJKIBA
|
7.7 | IC50 | 4 | — | |
KOCYTHSBSWIFSD
|
7.7 | IC50 | 5 | — | |
WFIJSNHJXOWVOT
|
7.7 | IC50 | 2 | — | |
WZQMZQPCSYFLOE
|
7.7 | IC50 | 4 | — | |
FZAUNVRSNYGSRM
|
7.7 | Kd | 4 | — | |
FIGYKDVBCKXPEA
|
7.7 | Kd | 4 | — | |
SIUIQMQVKUUQQF
|
7.7 | IC50 | 5 | — | |
ZLBVVUMOZWDVAU
|
7.7 | IC50 | 4 | — | |
AWHRFPLTQPNOTD
|
7.6 | IC50 | 5 | — | |
GFYZFDVAKCDQST
|
7.6 | IC50 | 5 | — | |
UUDAKQZBMTXFJA
|
7.6 | IC50 | 4 | — | |
AQXKGSIGOIIUJI
|
7.6 | IC50 | 4 | — |