Target Details
| UniProt AC | P53778 |
|---|---|
| Gene Symbol | MAPK12 |
| Protein Name | Mitogen-activated protein kinase 12 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 606
- Clinical molecules 10
- Avg pChEMBL 7.17
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (606)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WTYSITXLWIBADH
|
8.6 | IC50 | 4 | — | |
CUNDIGFRTACXCX
|
8.6 | IC50 | 4 | — | |
JPAXUPOTRXLXQE
|
8.6 | IC50 | 4 | — | |
DPSYCGMSLWKDDR
|
8.5 | Kd | 4 | — | |
NCFXYYJGQFCMMG
|
8.5 | IC50 | 4 | — | |
PFNBHJNERDWZGD
|
8.5 | Kd | 4 | — | |
RSCUAYDLLDUTKX
|
8.5 | IC50 | 4 | — | |
WQKREPZMMAPYRS
|
8.5 | IC50 | 4 | — | |
ZVXGJXOOHDCIBO
|
8.5 | Kd | 4 | — | |
KIJQUBGKXJVPER
|
8.5 | IC50 | 4 | — | |
DQXZQCNGYTVWJL
|
8.5 | IC50 | 4 | — | |
KGUYOFKQHDMARG
|
8.5 | IC50 | 4 | — | |
MMOVYTMEVBLPLX
|
8.5 | IC50 | 4 | — | |
OYOUIHFZUAKCEF
|
8.5 | IC50 | 4 | — | |
CCELPATZKCADOK
|
8.4 | IC50 | 4 | — | |
ANZAPACAXUOLFY
|
8.4 | Kd | 4 | — | |
VUBCLLUPUOLGKY
|
8.4 | IC50 | 4 | — | |
XAQAXLLEJACTLM
|
8.4 | IC50 | 4 | — | |
PNYSWMQVUBFTDP
|
8.4 | IC50 | 4 | — | |
RYMVWMWRYADLJC
|
8.4 | IC50 | 4 | — | |
KYTWYELKTBDZFP
|
8.4 | IC50 | 4 | — | |
CGTKKBWMFVAOFJ
|
8.4 | IC50 | 4 | — | |
KUGYCLJHAOPSBD
|
8.3 | Kd | 4 | — | |
OPENPZCNOHPQNG
|
8.3 | IC50 | 4 | — | |
SALBEPPKTYADGM
|
8.3 | IC50 | 4 | — | |
BOQNSWFZUHQNRG
|
8.2 | IC50 | 5 | — | |
RTEPGYYCYOJXTD
|
8.2 | IC50 | 4 | — | |
UGOQPKUREUTQEZ
|
8.2 | IC50 | 4 | — | |
UYMYCUSVHPBJBL
|
8.2 | IC50 | 4 | — | |
FQYJTHIYAQQJAB
|
8.2 | IC50 | 4 | — | |
ADQZGIYHFQQPRB
|
8.2 | IC50 | 10 | — | |
ILNRGJOBWHKROC
|
8.2 | IC50 | 4 | — | |
XEQBKWGVMSNLAI
|
8.2 | IC50 | 4 | — | |
XQKAXASIHJSCRN
|
8.2 | IC50 | 4 | — | |
RULGKKPHDCFAJF
|
8.2 | IC50 | 4 | — | |
WWTTXMQTJXMGQM
|
8.2 | IC50 | 4 | — | |
HRQLIPAWEHEJGG
|
8.1 | IC50 | 4 | — | |
WIIMYXRFJKRBLA
|
8.1 | IC50 | 4 | — | |
JEBBTQWFFYQVCM
|
8.1 | IC50 | 4 | — | |
HUIYFTUPVRGRGO
|
8.1 | Kd | 4 | — | |
KSCQZBDAQWTHKN
|
8.1 | IC50 | 4 | — | |
XIWRCSVXKPGGAJ
|
8.1 | Kd | 4 | — | |
QICPQLFMWYQJGX
|
8.1 | IC50 | 5 | — | |
AAIWZQZMQJIDII
|
8.1 | IC50 | 4 | — | |
DJIQDCXVLBGSFJ
|
8.1 | IC50 | 4 | — | |
FDVXDXGMVYUYFV
|
8.1 | IC50 | 4 | — | |
LSEQHHCLNCHKNO
|
8.1 | IC50 | 3 | — | |
ZMELOYOKMZBMRB
|
8.1 | IC50 | 4 | — | |
YBJHGWIVFMBWOO
|
8.0 | IC50 | 4 | — | |
ZDVAPIURGKFNMX
|
8.0 | IC50 | 4 | — |