Target Details
| UniProt AC | P53778 |
|---|---|
| Gene Symbol | MAPK12 |
| Protein Name | Mitogen-activated protein kinase 12 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 606
- Clinical molecules 10
- Avg pChEMBL 7.17
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (606)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IEIWIPIQYLVOCL
|
6.2 | IC50 | 3 | — | |
IKQIPPKRAFLUKQ
|
6.2 | IC50 | 4 | — | |
JDVWDZJXQUCOPW
|
6.2 | IC50 | 4 | — | |
NLHYRLRQFAKAFM
|
6.2 | IC50 | 4 | — | |
ZGZVRPRSFXRGCF
|
6.2 | Ki | 76 | — | |
BMLURWVFPXQDFS
|
6.2 | IC50 | 4 | — | |
JXPFBRYPSJLQII
|
6.2 | IC50 | 3 | — | |
RDRRLTKYMVDKDE
|
6.2 | IC50 | 5 | — | |
RDUXJEGWTNOYDA
|
6.2 | IC50 | 6 | — | |
VFDXVDLISMVQFY
|
6.2 | IC50 | 3 | — | |
GVGLHMXYNVASQP
|
6.2 | IC50 | 4 | — | |
XUJXJGOYKOTUOC
|
6.2 | IC50 | 4 | — | |
HBJKNJVTHNFOON
|
6.2 | IC50 | 4 | — | |
JLWQAVMMXAMIFK
|
6.2 | IC50 | 3 | — | |
NMEUKWOOQOHUNA
|
6.2 | IC50 | 6 | — | |
OKGRQZVTGRLIKW
|
6.2 | IC50 | 4 | — | |
WHXPUOMLBIINHX
|
6.2 | IC50 | 4 | — | |
JATKIRZRXGKMBU
|
6.1 | IC50 | 4 | — | |
KPYJFGGKRGRARF
|
6.1 | IC50 | 3 | — | |
AYKRXRVXSJGBJP
|
6.1 | IC50 | 4 | — | |
SFTNVXWKNHSZDN
|
6.1 | Kd | 4 | — | |
UPYYEIHAZSVKFD
|
6.1 | IC50 | 4 | — | |
ADMFLILDQJSEIK
|
6.1 | Ki | 72 | — | |
IGNVZQCPQGZXSY
|
6.1 | IC50 | 4 | — | |
PXRDIWAVNLQFBI
|
6.1 | IC50 | 6 | Yes | |
TXFGEKSPLVPFLN
|
6.1 | IC50 | 4 | — | |
WLLUQXGGNFUQGM
|
6.1 | Ki | 4 | — | |
JSARQMZOESQGPT
|
6.1 | IC50 | 3 | — | |
NEOFBONIFALDKM
|
6.1 | IC50 | 3 | — | |
AJIGCFPKVZIIGA
|
6.1 | IC50 | 4 | — | |
IAAZVAITVNPXCO
|
6.1 | IC50 | 5 | — | |
YNBVKQXDDAWGKI
|
6.1 | IC50 | 4 | — | |
KRRCAAGRJZQAMA
|
6.0 | IC50 | 4 | — | |
OGGGFMZSNXIFQY
|
6.0 | IC50 | 4 | — | |
IZVDYFCDVQANSW
|
6.0 | IC50 | 3 | — | |
RPSRGHSCASYFGD
|
6.0 | IC50 | 4 | — | |
HDUQKBUHXYJBEX
|
6.0 | IC50 | 5 | — | |
MMIOYPRRBPIXJS
|
6.0 | IC50 | 4 | — | |
PPZSTJQLZOPKBO
|
6.0 | IC50 | 3 | — | |
NXSJMRCTGYTSTK
|
6.0 | Kd | 200 | — | |
LHDHGTQRVCVMKJ
|
6.0 | IC50 | 5 | — | |
PNRBQMZDBPEICZ
|
6.0 | IC50 | 3 | — | |
ASWWEASHSSNEMM
|
6.0 | IC50 | 4 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
JCFJQIHDZHHMQT
|
6.0 | Ki | 42 | — | |
KCKXYZOBGBJZEG
|
6.0 | Ki | 36 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — | |
QONPPIZSNSSCSK
|
6.0 | Ki | 45 | Yes | |
QSXGIABTGIJOJX
|
6.0 | IC50 | 4 | — |