Target Details
| UniProt AC | P53778 |
|---|---|
| Gene Symbol | MAPK12 |
| Protein Name | Mitogen-activated protein kinase 12 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 606
- Clinical molecules 10
- Avg pChEMBL 7.17
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (606)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RRTXHGDCNJPJLH
|
6.5 | IC50 | 4 | — | |
UJPJYIXFJSSTRL
|
6.5 | IC50 | 4 | — | |
VDIYQHFWCBWRJR
|
6.5 | IC50 | 5 | — | |
XTWOWJJHYIIJNI
|
6.5 | IC50 | 4 | — | |
INOXXLKTFTWBBH
|
6.5 | IC50 | 4 | — | |
UKKGLZFUGQGJSZ
|
6.5 | IC50 | 4 | — | |
LJNWACYTYAWEFK
|
6.5 | IC50 | 4 | — | |
MIKAKZKNMYZLDX
|
6.5 | Ki | 42 | — | |
NTRGHFKSGIJGAD
|
6.5 | IC50 | 3 | — | |
WHKSAKSSQHTIKP
|
6.5 | IC50 | 4 | — | |
FDICHOOSBBHUQP
|
6.5 | Kd | 4 | — | |
VVGDYZAGZQTFBY
|
6.5 | IC50 | 4 | — | |
AFMLPWWCVUSWHH
|
6.5 | IC50 | 3 | — | |
MDQQAIUZIATVCK
|
6.5 | IC50 | 5 | — | |
QNNDHEPNDQDTBC
|
6.5 | IC50 | 4 | — | |
XYBYJNUTYQCHIH
|
6.5 | IC50 | 4 | — | |
AVUUHIYJPTWYNX
|
6.5 | IC50 | 9 | — | |
FWIJKWMXNHRSRO
|
6.5 | Kd | 4 | — | |
HYEOMJSVLMONGY
|
6.5 | IC50 | 4 | — | |
IVMWZPRCCDVEDY
|
6.5 | IC50 | 4 | — | |
OSYGDWRURYLVIZ
|
6.5 | IC50 | 2 | — | |
UBWALTPIDHCQBF
|
6.5 | IC50 | 3 | — | |
ANWRKPQVLGBTCG
|
6.4 | IC50 | 5 | — | |
JFBQFBISATWXFY
|
6.4 | IC50 | 4 | — | |
UBMXMXSQAQZMRL
|
6.4 | IC50 | 4 | — | |
WYGPCAVWWUKTAF
|
6.4 | IC50 | 4 | — | |
XVVXOPCGELRSQC
|
6.4 | IC50 | 4 | — | |
JXPKOFIOTMIADL
|
6.4 | IC50 | 4 | — | |
UIARLYUEJFELEN
|
6.4 | Kd | 289 | Yes | |
VXPWQNBKEIVYIS
|
6.4 | IC50 | 4 | — | |
BDGXAHBOBRAVIN
|
6.4 | IC50 | 3 | — | |
GPFDSPHUUASSEN
|
6.4 | IC50 | 4 | — | |
UTBOYGRCMFIHJK
|
6.4 | IC50 | 3 | — | |
CXQHYVUVSFXTMY
|
6.4 | Kd | 154 | — | |
NHHQJBCNYHBUSI
|
6.4 | Kd | 220 | — | |
SEJGTFPOEJWEGG
|
6.4 | Kd | 149 | — | |
ACYIZUWARCOLDC
|
6.4 | IC50 | 4 | — | |
BIIVYFLTOXDAOV
|
6.4 | Ki | 31 | — | |
CHTMRWQLNNRRFJ
|
6.4 | Ki | 70 | — | |
KXKFTUKPFILYNH
|
6.4 | IC50 | 4 | — | |
MKVNQJLMEFPKQR
|
6.4 | IC50 | 4 | — | |
NJPWCTYVEJIQBM
|
6.4 | Ki | 72 | — | |
NUQWXZVFQLROAQ
|
6.4 | IC50 | 4 | — | |
NVXXMMXIJGUQGI
|
6.4 | IC50 | 4 | — | |
PTVPBWWDGZSEAF
|
6.4 | Ki | 63 | — | |
SXWHZGGXJAJWCP
|
6.4 | IC50 | 4 | — | |
VXANPYYWKLKCMA
|
6.4 | Kd | 4 | — | |
WOUBHHLWOZLESX
|
6.4 | IC50 | 4 | — | |
PCJOCAVFVXDLHF
|
6.4 | IC50 | 3 | — | |
TVRPKAJOVUHTMP
|
6.4 | Kd | 4 | — |