Target Details
| UniProt AC | P53778 |
|---|---|
| Gene Symbol | MAPK12 |
| Protein Name | Mitogen-activated protein kinase 12 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 606
- Clinical molecules 10
- Avg pChEMBL 7.17
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (606)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XJGYVASDBIPRAF
|
10.3 | Ki | 4 | — | |
MXMWXOMNFWLHHQ
|
10.3 | Ki | 4 | — | |
UONISFJXHMSTQN
|
10.2 | Ki | 4 | — | |
VXWYKMMJKQFNRP
|
10.2 | Ki | 4 | — | |
IDTKLCNLVPKYPA
|
10.0 | Kd | 4 | — | |
QICPQLFMWYQJGX
|
10.0 | IC50 | 5 | — | |
TVPNMNQKHNYGNA
|
9.8 | Ki | 4 | — | |
ZXONHXQWZPBOLO
|
9.8 | IC50 | 4 | Yes | |
NVOVOGZPCHXJBQ
|
9.8 | Ki | 4 | — | |
GYCYTYZLLQPEBT
|
9.7 | IC50 | 4 | — | |
DYVTYPINLOPJMV
|
9.4 | Ki | 4 | — | |
QWHMQQHHLRCLLD
|
9.4 | Ki | 4 | — | |
XXAWRUNZQCOIKO
|
9.3 | IC50 | 4 | — | |
IHBPAWYBWDVDJK
|
9.3 | IC50 | 4 | — | |
GUJHNVVLTAXWRX
|
9.2 | IC50 | 4 | — | |
KFEQXUZWOONGQK
|
9.2 | IC50 | 4 | — | |
DEVGLXQREUCUSP
|
9.2 | Ki | 4 | — | |
PTPMBQNCXYRTGN
|
9.2 | IC50 | 5 | — | |
RVTPPRYTUBCENU
|
9.2 | IC50 | 4 | — | |
ZLQKJFNLHHGAQF
|
9.1 | IC50 | 5 | — | |
TZOYXRMEFDYWDQ
|
9.1 | IC50 | 4 | — | |
WLMGLORLNFEUDG
|
9.1 | IC50 | 4 | — | |
JGSOKYHCMXFSQG
|
9.0 | IC50 | 4 | — | |
HSQMAKZHOAZZPL
|
9.0 | Ki | 4 | — | |
GWCMRHRHTWMOLO
|
9.0 | IC50 | 4 | — | |
RHSMFYIHIIADSH
|
9.0 | Kd | 5 | — | |
YELORNJOYXXAFO
|
9.0 | IC50 | 4 | — | |
MFKZRXRMXDEYFP
|
8.9 | IC50 | 4 | — | |
MEMWBKJNZJSCOG
|
8.8 | IC50 | 4 | — | |
GGUFDSKGQOZGOY
|
8.8 | IC50 | 4 | — | |
LEQIYANLBCTNDM
|
8.8 | IC50 | 4 | — | |
ZXKCKRXMZFAGCD
|
8.8 | Ki | 4 | — | |
TWWUNSJOKCOGKZ
|
8.8 | IC50 | 4 | — | |
BSKASJBDVDOKBE
|
8.8 | IC50 | 4 | — | |
JLIDQWKTZPUAMJ
|
8.8 | Ki | 4 | — | |
KXNNHYBPDFMKQK
|
8.7 | IC50 | 4 | — | |
GDCTXLFXTKDKOE
|
8.7 | Ki | 4 | — | |
MBAYOYOHXJVBHG
|
8.7 | IC50 | 4 | — | |
SZRCCCNFNLAWGP
|
8.7 | IC50 | 4 | — | |
AKHMXEIJWVZWHP
|
8.7 | IC50 | 4 | — | |
CEZSPTXMXOJSRJ
|
8.7 | IC50 | 5 | — | |
CSVXUAKTJJDCMS
|
8.7 | IC50 | 6 | — | |
FRMOMXCMQJRNOS
|
8.7 | Kd | 4 | — | |
IOCRDUAOXZXTFV
|
8.7 | IC50 | 4 | — | |
LHVMOVISOAUTPX
|
8.7 | IC50 | 4 | — | |
WIGNNIARPGHXFO
|
8.7 | IC50 | 4 | — | |
XXCAPLNLONGIPM
|
8.7 | IC50 | 4 | — | |
PTPMBQNCXYRTGN
|
8.7 | IC50 | 4 | — | |
KFEQXUZWOONGQK
|
8.6 | IC50 | 4 | — | |
GXRLJHPCFBRKQO
|
8.6 | IC50 | 4 | — |