Target Details
| UniProt AC | P52564 |
|---|---|
| Gene Symbol | MAP2K6 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 6 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 17
- Clinical molecules 4
- Avg pChEMBL 6.83
KEGG Pathways (24)
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- Cellular senescence
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathways of neurodegeneration - multiple diseases
- Rap1 signaling pathway
- Salmonella infection
- TNF signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Yersinia infection
Active Molecules (17)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HKSZLNNOFSGOKW
|
8.5 | IC50 | 408 | — | |
HKSZLNNOFSGOKW
|
8.5 | Kd | 213 | — | |
OSVUGUHRKMMBSE
|
7.8 | Kd | 170 | — | |
NXSJMRCTGYTSTK
|
7.5 | Kd | 200 | — | |
ZCCPLJOKGAACRT
|
7.4 | Kd | 599 | — | |
UIARLYUEJFELEN
|
7.4 | Kd | 289 | Yes | |
KOZFSFOOLUUIGY
|
7.1 | Kd | 88 | Yes | |
LYADGAGFYYXXIO
|
6.5 | IC50 | 82 | — | |
NXWXUDHOUKWAQU
|
6.5 | Kd | 16 | — | |
QXPNJMHRUZCEAP
|
6.4 | IC50 | 14 | — | |
NHHQJBCNYHBUSI
|
6.3 | Kd | 220 | — | |
PBCZSGKMGDDXIJ
|
6.1 | Kd | 68 | Yes | |
YYLKKYCXAOBSRM
|
6.1 | Kd | 191 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
KDKUVYLMPJIGKA
|
6.0 | Kd | 91 | Yes | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — |