Target Details
| UniProt AC | P52333 |
|---|---|
| Gene Symbol | JAK3 |
| Protein Name | Tyrosine-protein kinase JAK3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 5,161
- Clinical molecules 45
- Avg pChEMBL 7.57
KEGG Pathways (15)
- Chemokine signaling pathway
- Epstein-Barr virus infection
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- JAK-STAT signaling pathway
- Measles
- Necroptosis
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Primary immunodeficiency
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Viral carcinogenesis
Associated Diseases (1)
Active Molecules (5,161)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VQIIUJSNIKEMCK
|
10.2 | Ki | 4 | — | |
MAZJNLNOQXQFPU
|
10.2 | IC50 | 2 | — | |
XNDQNBFQNOZWQD
|
10.2 | IC50 | 2 | — | |
IWQGAESJHGYTDV
|
10.2 | IC50 | 2 | — | |
RUGKMJBVTQEPHN
|
10.1 | IC50 | 2 | — | |
PLOAUINIELSVFC
|
10.1 | Ki | 4 | — | |
UWZLUJZCOIATJC
|
10.1 | Ki | 4 | — | |
VVUPFHUSDJLFEM
|
10.1 | Ki | 4 | — | |
ZVYNVRJNUSIWHA
|
10.0 | IC50 | 2 | — | |
SHSYAACXYIUJOR
|
10.0 | IC50 | 2 | — | |
DJUAJWMTCKJXRM
|
10.0 | Kd | 4 | — | |
AVYPELRFUAVSMJ
|
10.0 | IC50 | 3 | — | |
BAHITJWCHBRYNZ
|
10.0 | Ki | 4 | — | |
BOBFKXIKGHTPJB
|
10.0 | IC50 | 2 | — | |
DWSHMTRKCGSRHM
|
10.0 | Ki | 4 | — | |
FLYSMHZPSXRHSX
|
10.0 | IC50 | 2 | — | |
FMQJJFMKSBZQNO
|
10.0 | IC50 | 3 | — | |
HKPSTIOXMRBTFB
|
10.0 | IC50 | 2 | — | |
ILLPIKJJGYAYLB
|
10.0 | IC50 | 2 | — | |
LKYNKWVSJBBRNP
|
10.0 | Ki | 4 | — | |
UKCXKMIKWBUVSF
|
10.0 | IC50 | 2 | — | |
WSMBMGDMRYONOH
|
10.0 | IC50 | 2 | — | |
XBTXQBXZRIJGLX
|
10.0 | IC50 | 2 | — | |
XPZRPHWBCYPZRY
|
10.0 | IC50 | 2 | — | |
XNPPMSODZPSJBF
|
10.0 | IC50 | 2 | — | |
QFZBBBNYHMUAIF
|
9.9 | IC50 | 2 | — | |
PRTCQOVBVGCUBR
|
9.9 | IC50 | 4 | — | |
KAVVKRQBEAWLIE
|
9.9 | Ki | 4 | — | |
ALTGJIWLNXJYNC
|
9.9 | IC50 | 3 | — | |
CQVLTKQROAIZOC
|
9.9 | Ki | 2 | — | |
LKYNKWVSJBBRNP
|
9.9 | Ki | 2 | — | |
NPXRGBHWBLKOFJ
|
9.9 | Ki | 2 | — | |
QYNXLJMXRRLLMI
|
9.9 | IC50 | 3 | — | |
RNWGSYOIILQORV
|
9.9 | Ki | 4 | — | |
YEWZGSYTWIEWEI
|
9.9 | IC50 | 2 | — | |
PLALKTRHBMUZHB
|
9.9 | IC50 | 3 | — | |
WRAJCGKEBIJMIV
|
9.9 | IC50 | 2 | — | |
NKIGZOJXNGMDHT
|
9.9 | IC50 | 2 | — | |
XGRFWJQVCIPXOC
|
9.9 | IC50 | 2 | — | |
XJTGGWJJJUHEMZ
|
9.9 | IC50 | 2 | — | |
SNVFGNBQSYUPIG
|
9.8 | IC50 | 2 | — | |
IFMUWEIRUHMMIT
|
9.8 | IC50 | 3 | — | |
NJPHKVOXHRAPGJ
|
9.8 | IC50 | 2 | — | |
FMTAVWMGYFGNIB
|
9.8 | IC50 | 3 | — | |
BTNXVVHACPIWSH
|
9.8 | IC50 | 5 | — | |
BXGXGNMIGPBZRW
|
9.8 | IC50 | 3 | — | |
CVHSFUPKHBNGLI
|
9.8 | Ki | 2 | — | |
CVHSFUPKHBNGLI
|
9.8 | Ki | 2 | — | |
DFAZSOUFLNOONE
|
9.8 | Ki | 4 | — | |
DFAZSOUFLNOONE
|
9.8 | Ki | 4 | — |