Target Details
| UniProt AC | P52333 |
|---|---|
| Gene Symbol | JAK3 |
| Protein Name | Tyrosine-protein kinase JAK3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 5,161
- Clinical molecules 45
- Avg pChEMBL 7.57
KEGG Pathways (15)
- Chemokine signaling pathway
- Epstein-Barr virus infection
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- JAK-STAT signaling pathway
- Measles
- Necroptosis
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Primary immunodeficiency
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Viral carcinogenesis
Associated Diseases (1)
Active Molecules (5,161)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OKNGBMISBWKGAC
|
12.1 | IC50 | 2 | — | |
SMPSLOLOVXFPCR
|
11.9 | IC50 | 2 | — | |
PDOGAEAFDICXFC
|
11.9 | IC50 | 2 | — | |
JCYROZOHYWKFQS
|
11.8 | IC50 | 2 | — | |
BWZWPXZXRGUPNX
|
11.8 | IC50 | 2 | — | |
QHRMQKJISSPTFZ
|
11.5 | IC50 | 2 | — | |
XIPYVIOWRGYLFI
|
11.5 | IC50 | 2 | — | |
RMSRKKFWYZMWLY
|
11.5 | IC50 | 2 | — | |
GEBIRRZRZLCAHK
|
11.4 | IC50 | 2 | — | |
HACRCBAIIDXXCJ
|
11.4 | IC50 | 2 | — | |
UVWWSVLFELMDEN
|
11.3 | IC50 | 2 | — | |
HBJWGPOVAOVPGD
|
11.3 | IC50 | 2 | — | |
BNFKFVISRQDWHB
|
11.3 | IC50 | 2 | — | |
WWJGFVVXHNAPOB
|
11.3 | IC50 | 2 | — | |
YBAFPAFESOTFOQ
|
11.3 | IC50 | 2 | — | |
ZPMOMQNJSGBBAD
|
11.2 | IC50 | 2 | — | |
VNDHJWSNDHLJRC
|
11.2 | IC50 | 2 | — | |
SXFUYVYSIDXMPH
|
11.2 | IC50 | 2 | — | |
AQGDWJQZAICCQE
|
11.0 | IC50 | 2 | — | |
NONQHXZJSJTQSM
|
11.0 | IC50 | 2 | — | |
JQGRGIAYUIEXHU
|
11.0 | IC50 | 2 | — | |
MNLRALLJFYLNRI
|
11.0 | IC50 | 2 | — | |
GOZFKFAFAJSLCX
|
10.9 | IC50 | 2 | — | |
GQAYABNMBBTJFN
|
10.9 | IC50 | 2 | — | |
SBOGQLBMEWOYIL
|
10.9 | IC50 | 2 | — | |
QJWRQIVEMXYWAK
|
10.9 | IC50 | 2 | — | |
LUXSOKJTOICWHQ
|
10.8 | IC50 | 2 | — | |
MXDGOCGSIURVTR
|
10.8 | IC50 | 2 | — | |
SLZJYSDUTDXKHL
|
10.8 | IC50 | 3 | — | |
JRWRRAPGXSPUQD
|
10.8 | IC50 | 3 | — | |
GCRPKZFLZHBPJI
|
10.8 | Ki | 2 | — | |
IEZRZUHSKFJPQY
|
10.8 | IC50 | 2 | — | |
QUTDVGIAVRPCRG
|
10.8 | IC50 | 2 | — | |
RGYINCLTDOJACX
|
10.8 | IC50 | 2 | — | |
HPYIEWCWRQCQOL
|
10.8 | IC50 | 3 | — | |
UPKJSCTVENSCCN
|
10.8 | IC50 | 2 | — | |
GKMDQFMGAVLZKR
|
10.8 | IC50 | 2 | — | |
NONQHXZJSJTQSM
|
10.8 | IC50 | 2 | — | |
VFFDONNNTMZBAM
|
10.8 | IC50 | 3 | — | |
WYHTYLVLSXUWPH
|
10.7 | IC50 | 2 | — | |
ONAPNRXZQWBOTL
|
10.7 | IC50 | 3 | — | |
AVZLKLPFHIKARU
|
10.7 | IC50 | 2 | — | |
QOEZRZBVPCWVFJ
|
10.7 | IC50 | 2 | — | |
YISMQBFJYDFMAL
|
10.7 | IC50 | 46 | — | |
UXPYEJLTPMRCCL
|
10.7 | IC50 | 2 | — | |
WFOJKBCSVXKTOA
|
10.7 | IC50 | 3 | — | |
SCNCLWXRXWWBQJ
|
10.7 | IC50 | 2 | — | |
HJWYZAOXQLPRRD
|
10.7 | IC50 | 2 | — | |
HSAKOHADCPEPRG
|
10.6 | IC50 | 2 | — | |
ODDNPGSYZFWGMF
|
10.6 | IC50 | 2 | — |