Target Details
| UniProt AC | P51692 |
|---|---|
| Gene Symbol | STAT5B |
| Protein Name | Signal transducer and activator of transcription 5B |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00017 (SH2) PF01017 (STAT_alpha) PF02864 (STAT_bind) PF02865 (STAT_int) PF21354 (STAT_linker) |
Summary
- Multi-target molecules 5
- Clinical molecules 0
- Avg pChEMBL 6.78
KEGG Pathways (19)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Chronic myeloid leukemia
- ErbB signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- JAK-STAT signaling pathway
- Measles
- Necroptosis
- Non-small cell lung cancer
- Pathways in cancer
- Prolactin signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Viral carcinogenesis
Associated Diseases (1)
Active Molecules (5)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MWKSRKSEWLRPBL
|
8.4 | Kd | 1075 | — | |
AMYVQFXKGYPZLQ
|
7.1 | Kd | 2 | — | |
QOYWPVULYMHMHY
|
6.4 | Ki | 2 | — | |
CISYTKIPJVVEHB
|
6.0 | Ki | 2 | — | |
KJJHAYNANYPNEE
|
6.0 | Ki | 2 | — |