Target Details
| UniProt AC | P51617 |
|---|---|
| Gene Symbol | IRAK1 |
| Protein Name | Interleukin-1 receptor-associated kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00531 (Death) PF00069 (Pkinase) |
Summary
- Multi-target molecules 312
- Clinical molecules 15
- Avg pChEMBL 6.84
KEGG Pathways (20)
- Alcoholic liver disease
- Chagas disease
- Coronavirus disease - COVID-19
- Epstein-Barr virus infection
- Hepatitis B
- Herpes simplex virus 1 infection
- Human immunodeficiency virus 1 infection
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- NF-kappa B signaling pathway
- Neurotrophin signaling pathway
- Pathogenic Escherichia coli infection
- Pertussis
- Salmonella infection
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Yersinia infection
Active Molecules (312)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HXEIWJBTKNXMHO
|
6.0 | IC50 | 2 | — | |
BPNUQXPIQBZCMR
|
6.0 | Ki | 60 | — | |
CKVWQORGCCEYHS
|
6.0 | Ki | 50 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
JCFJQIHDZHHMQT
|
6.0 | Ki | 42 | — | |
JRVSFZKYQCETAH
|
6.0 | Ki | 19 | — | |
LCGSWTFWYNYUKS
|
6.0 | Ki | 26 | — | |
NGDNKYRUKIPCLK
|
6.0 | Ki | 12 | — | |
QUZYEJUYJAWLOF
|
6.0 | Ki | 4 | — | |
UVZVWLFSZNPMBS
|
6.0 | Ki | 17 | — | |
XCHWBXBDZRJVDP
|
6.0 | Ki | 51 | — | |
ZKHDDJKHTPLPOQ
|
6.0 | Ki | 62 | — |