Target Details
| UniProt AC | P50993 |
|---|---|
| Gene Symbol | ATP1A2 |
| Protein Name | Sodium/potassium-transporting ATPase subunit alpha-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF13246 (Cation_ATPase) PF00689 (Cation_ATPase_C) PF00690 (Cation_ATPase_N) PF00122 (E1-E2_ATPase) |
Summary
- Multi-target molecules 134
- Clinical molecules 0
- Avg pChEMBL 6.93
KEGG Pathways (19)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Bile secretion
- Carbohydrate digestion and absorption
- Cardiac muscle contraction
- Cytoskeleton in muscle cells
- Endocrine and other factor-regulated calcium reabsorption
- Gastric acid secretion
- Insulin secretion
- Mineral absorption
- Pancreatic secretion
- Protein digestion and absorption
- Proximal tubule bicarbonate reclamation
- Salivary secretion
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (3)
Active Molecules (134)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
BYXAGCCQDSIWHH
|
6.3 | IC50 | 8 | — | |
GLGPOUSKXSNBBO
|
6.3 | IC50 | 8 | — | |
WUBIBGYWUZUNNR
|
6.3 | IC50 | 8 | — | |
BPOCXSHOKZMVTQ
|
6.3 | IC50 | 8 | — | |
YFXRIQXHJOWDIA
|
6.2 | IC50 | 8 | — | |
XCZZVTGAOFXVRN
|
6.2 | IC50 | 8 | — | |
WVEGAINMKWGMQF
|
6.2 | IC50 | 8 | — | |
BYZKQAJRHRSLFB
|
6.2 | IC50 | 8 | — | |
PWSSKBVUJWPAKP
|
6.2 | IC50 | 8 | — | |
WUEJJDAJHZAUTN
|
6.2 | IC50 | 8 | — | |
CKATWOIVYBOFBX
|
6.2 | IC50 | 8 | — | |
NOMWIENSVSSXLM
|
6.1 | IC50 | 8 | — | |
OCHFCLLFHZJODH
|
6.1 | IC50 | 8 | — | |
RYPLJABMUJCZDP
|
6.1 | IC50 | 8 | — | |
AHMFXCKPRYTDAX
|
6.1 | IC50 | 8 | — | |
DUBHNQVGESAENE
|
6.1 | IC50 | 8 | — | |
SKXWHUZZZUAUTR
|
6.1 | IC50 | 8 | — | |
UPGRUNNGGMKRNL
|
6.1 | IC50 | 8 | — | |
YNSPHTBZQCLQTP
|
6.1 | IC50 | 8 | — | |
ZONVAXBTJUJNEV
|
6.1 | IC50 | 8 | — | |
YCTOKVWDUCMPQH
|
6.1 | IC50 | 8 | — | |
DVNONHRZPHVBRC
|
6.1 | IC50 | 8 | — | |
MNEBYGGATWLYSQ
|
6.0 | IC50 | 8 | — | |
SCSFIKPKBXJODT
|
6.0 | IC50 | 8 | — | |
UUJNDNMWRJVROK
|
6.0 | IC50 | 8 | — | |
BXTBYVDGHWICHN
|
6.0 | IC50 | 8 | — | |
CRFODPKTNNHLHW
|
6.0 | IC50 | 8 | — | |
FANGVRWQNKXROL
|
6.0 | IC50 | 8 | — | |
FFUHYVXTLIVSQO
|
6.0 | IC50 | 8 | — | |
KTLHLIXDVWEQDP
|
6.0 | IC50 | 8 | — | |
OMIMFIZVMAZVGL
|
6.0 | IC50 | 8 | — | |
WUBIBGYWUZUNNR
|
6.0 | IC50 | 8 | — | |
XJJAPQDCCAHZKH
|
6.0 | IC50 | 8 | — | |
ZAVBVROOKBXWAZ
|
6.0 | IC50 | 8 | — |