Target Details
| UniProt AC | P50993 |
|---|---|
| Gene Symbol | ATP1A2 |
| Protein Name | Sodium/potassium-transporting ATPase subunit alpha-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF13246 (Cation_ATPase) PF00689 (Cation_ATPase_C) PF00690 (Cation_ATPase_N) PF00122 (E1-E2_ATPase) |
Summary
- Multi-target molecules 134
- Clinical molecules 0
- Avg pChEMBL 6.93
KEGG Pathways (19)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Aldosterone-regulated sodium reabsorption
- Bile secretion
- Carbohydrate digestion and absorption
- Cardiac muscle contraction
- Cytoskeleton in muscle cells
- Endocrine and other factor-regulated calcium reabsorption
- Gastric acid secretion
- Insulin secretion
- Mineral absorption
- Pancreatic secretion
- Protein digestion and absorption
- Proximal tubule bicarbonate reclamation
- Salivary secretion
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (3)
Active Molecules (134)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RHMPRGRMPQFVCB
|
7.1 | IC50 | 8 | — | |
CFQQWIGJDYSXSJ
|
7.1 | IC50 | 8 | — | |
YFGQSHQFNJYAMR
|
7.1 | IC50 | 8 | — | |
CMHWMOGWFZWDMR
|
7.1 | IC50 | 8 | — | |
XDRNASYUVVKVMX
|
7.1 | IC50 | 8 | — | |
LPMXVESGRSUGHW
|
7.0 | Ki | 3 | — | |
DCXOCWYTNAVQBU
|
7.0 | IC50 | 8 | — | |
DUBHNQVGESAENE
|
7.0 | IC50 | 8 | — | |
IESYRFMTAXZLKS
|
7.0 | IC50 | 8 | — | |
OAFIVRUVYWMTHX
|
7.0 | IC50 | 8 | — | |
VPAJCNIPFWHYII
|
7.0 | IC50 | 8 | — | |
IJRWRMFNPYXLPH
|
6.9 | IC50 | 8 | — | |
SHIBSTMRCDJXLN
|
6.9 | Ki | 4 | — | |
SIPIQHFHHIBYBL
|
6.9 | Ki | 2 | — | |
VZYQNOPWCYKLPX
|
6.9 | IC50 | 8 | — | |
BWIFYTYSHZTELV
|
6.9 | Ki | 5 | — | |
FBQSRPQVIDAAJA
|
6.9 | Ki | 2 | — | |
HTOFZPAXYVFIHZ
|
6.8 | Ki | 2 | — | |
UTBUBDRWYBHXFC
|
6.8 | Ki | 2 | — | |
GLGPOUSKXSNBBO
|
6.8 | IC50 | 8 | — | |
UNBZAUBSKHTVIH
|
6.8 | IC50 | 8 | — | |
FHRFLDXBGQKLCM
|
6.8 | IC50 | 8 | — | |
LQVQTKIMPALRSS
|
6.8 | IC50 | 8 | — | |
AKSKNPAPGBRSAB
|
6.7 | IC50 | 8 | — | |
FUGVPVYKBGWZMC
|
6.7 | IC50 | 8 | — | |
GIZAEZPLWLWLLO
|
6.7 | IC50 | 8 | — | |
KOVYNKCVYRFQCO
|
6.7 | IC50 | 8 | — | |
MKIKNZBEAPEHTK
|
6.7 | IC50 | 8 | — | |
RSVKUSZQRGINEO
|
6.7 | IC50 | 8 | — | |
RXAQOPSWCQZTHW
|
6.7 | IC50 | 9 | — | |
DUBHNQVGESAENE
|
6.6 | IC50 | 8 | — | |
FDRCYIBWOFKICN
|
6.6 | IC50 | 8 | — | |
GWVOOOKBHJEJJJ
|
6.6 | IC50 | 8 | — | |
IJRWRMFNPYXLPH
|
6.6 | IC50 | 9 | — | |
WVEGAINMKWGMQF
|
6.6 | IC50 | 8 | — | |
SBNDJGPFJSWZQO
|
6.6 | IC50 | 8 | — | |
KGKCYVKDIMEFFP
|
6.6 | IC50 | 8 | — | |
FNMNIFYGWCVBNZ
|
6.5 | IC50 | 8 | — | |
QFWMWJKYDUARDJ
|
6.5 | Ki | 8 | — | |
SJBJFBWDCMUDLX
|
6.5 | IC50 | 8 | — | |
BJTJHPNQMGQVLK
|
6.4 | IC50 | 8 | — | |
PDHCFMSBVAKZJF
|
6.4 | IC50 | 8 | — | |
AOJWIMOZVSIYID
|
6.4 | IC50 | 8 | — | |
BHORUCIVHSYUOS
|
6.4 | Ki | 2 | — | |
CKPNOQUCOCLXEJ
|
6.4 | IC50 | 8 | — | |
FHRFLDXBGQKLCM
|
6.4 | IC50 | 8 | — | |
RHMPRGRMPQFVCB
|
6.4 | IC50 | 8 | — | |
KPIHBTYGWSGVMC
|
6.4 | IC50 | 8 | — | |
OBLROXFEDYVPLD
|
6.4 | IC50 | 8 | — | |
YTVVIRMXLLFOAP
|
6.3 | IC50 | 8 | — |