Target Details
| UniProt AC | P50148 |
|---|---|
| Gene Symbol | GNAQ |
| Protein Name | Guanine nucleotide-binding protein G(q) subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00503 (G-alpha) |
Summary
- Multi-target molecules 2
- Clinical molecules 0
- Avg pChEMBL 7.25
KEGG Pathways (50)
- Adrenergic signaling in cardiomyocytes
- African trypanosomiasis
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amoebiasis
- Apelin signaling pathway
- Calcium signaling pathway
- Chagas disease
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Estrogen signaling pathway
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hormone signaling
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Long-term depression
- Long-term potentiation
- Melanogenesis
- Neuroactive ligand signaling
- Oxytocin signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Platelet activation
- Rap1 signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone synthesis
- Vascular smooth muscle contraction
- Yersinia infection
- cGMP-PKG signaling pathway
Associated Diseases (2)
Top Co-occurrence Targets
- GNA11 2 shared
Active Molecules (2)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IMXKHFILKMPFGB
|
7.5 | IC50 | 2 | — | |
QVYLWCAYZGFGNF
|
7.0 | IC50 | 2 | — |