Target Details
| UniProt AC | P49841 |
|---|---|
| Gene Symbol | GSK3B |
| Protein Name | Glycogen synthase kinase-3 beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 2,206
- Clinical molecules 168
- Avg pChEMBL 7.19
KEGG Pathways (49)
- Alcoholic liver disease
- Alzheimer disease
- Axon guidance
- B cell receptor signaling pathway
- Basal cell carcinoma
- Breast cancer
- Cadherin signaling
- Cell cycle
- Chemokine signaling pathway
- Colorectal cancer
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human cytomegalovirus infection
- Human papillomavirus infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Measles
- Melanogenesis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- PI3K-Akt signaling pathway
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Prolactin signaling pathway
- Prostate cancer
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Wnt signaling pathway
- Yersinia infection
- mTOR signaling pathway
Active Molecules (2,206)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZDPGLLQANLROFM
|
6.2 | Ki | 17 | — | |
BBCSUMURJUYILA
|
6.2 | IC50 | 10 | — | |
CHGLHVVJPSESHY
|
6.2 | IC50 | 4 | — | |
HENXDAXZQIPSPS
|
6.2 | Ki | 2 | — | |
PRIGRJPRGZCFAS
|
6.2 | IC50 | 13 | Yes | |
PTDUHCKFWWNGET
|
6.2 | Ki | 2 | — | |
QJIKOODYNZFJFF
|
6.2 | IC50 | 3 | Yes | |
ZGEQEMOJHVPNTB
|
6.2 | IC50 | 2 | — | |
AYCPARAPKDAOEN
|
6.2 | Kd | 73 | — | |
CBJJFDXVIBAIJJ
|
6.2 | Ki | 2 | — | |
FQVIXEWPVFCXAH
|
6.2 | Ki | 3 | — | |
GNNGWQSTNJCADU
|
6.2 | Ki | 4 | Yes | |
NCFYJNPNQNEPRW
|
6.2 | IC50 | 2 | — | |
OTKQTETZDVGXBV
|
6.2 | IC50 | 4 | — | |
QMUKOEKTUBVPFU
|
6.2 | IC50 | 12 | — | |
RZIDZIGAXXNODG
|
6.2 | IC50 | 5 | — | |
SSNQAUBBJYCSMY
|
6.2 | IC50 | 5 | — | |
UIVOWAUHPLCYNK
|
6.2 | IC50 | 2 | — | |
YGVLUDLFNRZMNT
|
6.2 | IC50 | 8 | — | |
YRYHREVRGLXBSJ
|
6.2 | IC50 | 2 | — | |
ZGBAGWYVESAQAG
|
6.2 | IC50 | 6 | — | |
AQJWACKPYCXBCF
|
6.2 | IC50 | 4 | — | |
FYXULBBAJZXNDR
|
6.2 | IC50 | 2 | — | |
ZUFPYCGWUXYDBH
|
6.2 | IC50 | 4 | — | |
AWINCECFBWDQTG
|
6.2 | IC50 | 2 | — | |
AYGAZNIMFAQJIL
|
6.2 | Ki | 3 | — | |
FQGPBKNLANMDDC
|
6.2 | IC50 | 3 | — | |
GBRORGYPYNNDGL
|
6.2 | IC50 | 3 | Yes | |
HASUWNAFLUMMFI
|
6.2 | IC50 | 2 | — | |
HCRQPXYLXXLKPT
|
6.2 | Ki | 5 | — | |
JDSJDASOXWCHPN
|
6.2 | IC50 | 2 | — | |
LOOYKDRIOSVHMM
|
6.2 | IC50 | 2 | Yes | |
OXYHNOHLBLUYKQ
|
6.2 | IC50 | 2 | — | |
RPWRQYOHVXHGBO
|
6.2 | IC50 | 4 | — | |
VJPQVJGSYWEPEZ
|
6.2 | Ki | 2 | — | |
NZWOOXILJLNOHZ
|
6.2 | IC50 | 2 | — | |
OAVGBZOFDPFGPJ
|
6.2 | IC50 | 42 | Yes | |
QFVOPUFBADFYEL
|
6.2 | IC50 | 3 | — | |
VPDNRVAEXHLDOA
|
6.2 | IC50 | 2 | — | |
VTWFAMNLMPQFEP
|
6.2 | IC50 | 2 | — | |
YQOFNVLHDVALER
|
6.2 | IC50 | 2 | — | |
BIIVYFLTOXDAOV
|
6.1 | Kd | 29 | — | |
BIIVYFLTOXDAOV
|
6.1 | Kd | 82 | Yes | |
GUBJNPWVIUFSTR
|
6.1 | Kd | 103 | — | |
CJUCGJVXCMUBQK
|
6.1 | IC50 | 2 | — | |
JTKFRFMSUBOCIQ
|
6.1 | IC50 | 4 | Yes | |
VSEUBSIOCPHOEN
|
6.1 | IC50 | 2 | — | |
VZPARCWZOQHETM
|
6.1 | IC50 | 2 | — | |
BDRSCIWOUKYOAH
|
6.1 | IC50 | 2 | — | |
CYGJLKBTKVKZQE
|
6.1 | IC50 | 6 | — |