Target Details
| UniProt AC | P49841 |
|---|---|
| Gene Symbol | GSK3B |
| Protein Name | Glycogen synthase kinase-3 beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 2,206
- Clinical molecules 168
- Avg pChEMBL 7.19
KEGG Pathways (49)
- Alcoholic liver disease
- Alzheimer disease
- Axon guidance
- B cell receptor signaling pathway
- Basal cell carcinoma
- Breast cancer
- Cadherin signaling
- Cell cycle
- Chemokine signaling pathway
- Colorectal cancer
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human cytomegalovirus infection
- Human papillomavirus infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Measles
- Melanogenesis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- PI3K-Akt signaling pathway
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Prolactin signaling pathway
- Prostate cancer
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Wnt signaling pathway
- Yersinia infection
- mTOR signaling pathway
Active Molecules (2,206)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NGFGTMFVWSDFPS
|
6.8 | IC50 | 32 | — | |
NOUFXHPCDFRAAM
|
6.8 | IC50 | 2 | — | |
RVXAVLKJEPIRIR
|
6.8 | Ki | 2 | — | |
RYBNARZBIXTFJS
|
6.8 | IC50 | 9 | — | |
SJOKPCUBKAMNFF
|
6.8 | Ki | 3 | — | |
TVXWKAUMIVTQTA
|
6.8 | IC50 | 4 | — | |
UNXKPCQXZUAGGJ
|
6.8 | IC50 | 2 | — | |
WMSHTIRWIOFMAY
|
6.8 | IC50 | 3 | — | |
ANHNZYQVWLXJET
|
6.8 | IC50 | 2 | — | |
WSBSGWDWALJLJA
|
6.8 | IC50 | 2 | — | |
BQWBZBFRJHWSEA
|
6.8 | IC50 | 5 | — | |
DZCWNAMURCVSNJ
|
6.8 | Ki | 4 | — | |
FULBTJANHDAKTA
|
6.8 | IC50 | 5 | — | |
GHPFSYCYZJKVDZ
|
6.8 | Ki | 18 | Yes | |
GPKQGYSDQQIJLW
|
6.8 | Ki | 19 | — | |
HNXJWWRRSGDVIW
|
6.8 | Ki | 13 | — | |
JGBCLJZMLUMHOO
|
6.8 | Ki | 6 | — | |
JPLLQSBSTHWUIK
|
6.8 | IC50 | 7 | — | |
LHQWPYOYDRVMFI
|
6.8 | Ki | 21 | — | |
NBLFGELIWIKRAC
|
6.8 | Ki | 8 | — | |
OROAFGSTGRDOFR
|
6.8 | Ki | 6 | — | |
PCQMERRARZKTPW
|
6.8 | Ki | 68 | — | |
PMXPVPGZZRMXIV
|
6.8 | Ki | 8 | — | |
QNUKRWAIZMBVCU
|
6.8 | Ki | 46 | — | |
SOVYWBOZOBVFLP
|
6.8 | Ki | 10 | — | |
SPOBBSBKXJKGBG
|
6.8 | Ki | 16 | — | |
YGEACCLUBSGMMJ
|
6.8 | Ki | 16 | — | |
ZBELDPMWYXDLNY
|
6.8 | IC50 | 4 | — | |
ZPXPEKQMLOAPLT
|
6.8 | Ki | 15 | — | |
BDNALELXSRUQLO
|
6.8 | IC50 | 2 | — | |
CBQODTLCGVMLQR
|
6.8 | IC50 | 2 | — | |
PSLRGVBAUBPLDY
|
6.8 | IC50 | 2 | — | |
WFCKUPLLUJUYHP
|
6.8 | IC50 | 2 | — | |
WXRFLOKAMNTJSD
|
6.8 | Ki | 3 | — | |
XMKRZXOTGFXMPH
|
6.8 | IC50 | 5 | — | |
FNOUTFPQMJNBDX
|
6.8 | IC50 | 3 | — | |
MYBZDSDFVPDTCR
|
6.8 | IC50 | 2 | — | |
ABQLVQSYGVOLAD
|
6.8 | IC50 | 2 | — | |
IEBPZCOLCOJVHI
|
6.8 | IC50 | 2 | — | |
NOOMEBXFKHIBIE
|
6.8 | IC50 | 2 | — | |
QITTZHVXBHDUGY
|
6.8 | Ki | 5 | Yes | |
QIYXLIZWXGGKOO
|
6.8 | IC50 | 10 | — | |
UNPCCYFJMCHROL
|
6.8 | IC50 | 2 | — | |
WSUSQFQQODISNM
|
6.8 | IC50 | 3 | Yes | |
BIAAOBDEULESPH
|
6.8 | IC50 | 2 | — | |
IFNFYBNUPMANII
|
6.8 | IC50 | 2 | — | |
RMLWKXHTADHNDS
|
6.8 | IC50 | 2 | — | |
URXYIEHEYCMTHH
|
6.8 | IC50 | 3 | — | |
ZZRDSHKJUCIYQL
|
6.8 | IC50 | 2 | — | |
NDXJIXWTFPGHAI
|
6.8 | IC50 | 2 | — |